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Mlsc 407:Histopothology And Cytoplogy Question Paper
Mlsc 407:Histopothology And Cytoplogy
Course:Masters In Medical Laboratory
Institution: Kenya Methodist University question papers
Exam Year:2013
KENYA METHODIST UNIVERSITY
END OF 1''ST ''TRIMESTER 2013 EXAMINATION
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY SCIENCES
UNIT CODE : MLSC 407
UNIT TITLE : HISTOPATHOLOGY & CYTOLOGY
TIME : 2 HOURS
SECTION A: COMPULSORY (20 MARKS)
Question One
Which of the following term refers to the study of diseases due to cell changes following injury.
Pathogenesis
Pathology
Morphology
Clinical significance
Question Two
Which of the following refer to programmed cell death.
Necrosis
Apoptosis
Ischeamia
Infarction
Question Three
The dead cells in necrosis assume following changes by fragmentation of nuclei material.
Kayolysis
Pyknosis
Gangrenous
Karryorrhexis
Question Four
The following is cellular adaptation characterized by increase of cell numbers in a tissue.
Atrophy
Hyperplasia
Hypertrophy
Metaplasia
Question Five
Fat deposition accumulation in tissue is referred to as:
Steatosis
Xathomas
Anthracosis
Heamosederosis
Question Six
Deposition calcium areas of necrosis is referred to as;
Metastatic calcification
Destruction of bone
Dystrophic calcification
Hyperparathyroidsm
Question Seven
Chronic inflammation may be demonstrated by the following changes except:
Vascular changes
Infiltration of monocytes
Tissue destruction
Repair
Question Eight
Which of the following cells are cells of acute inflammation response?
Plasma cells
Macrophages
Oesinophils
Lymphocytes
Question Nine
Which of the following represent correct cellualar events in acute inflammation.
Margination – Rolling –Adhesion – Transmigration
Transmigration-Adhesion – Rolling – Migration
Adhesion – Rolling – Margination – Transmigration
Rolling- Margination – Adhesion – Transmigration
Question Ten
The following is outcomes of acute inflammation:
Granulomates formation
Abscess formation
Necrosis
Fibrosing
Question Eleven
Grocotts stain is preferred for tissue demonstratin for the following.
Spirochetes
Mucins
Viruses
Fungal elements
Question Twelve
Prusian blue stain impregnation can demonstrate one of following in tissue staining.
Reticulin fibres
Melanin
Ferric salts
Mitochodria
Question Thirteen
Acute inflammation is mostly characterized by the one of the following:
Vascular dilation
Deformation of joints by fibroisis
Macrophages infiltration
Granulation tissue formation.
Question Fourteen
The specimen after collection for cytological studies (Pap smear, FNA) are normally fixed in one of the following:
In 95% Ethyl ether
In 100% xylene
In 40% formal saline
In 10% formaline
Question Fifteen
In tissue processing for microtomy which is the last step after trimming of the specimen:
Staining with haematoxylin and rosin.
Dehydration
Hydration
Embedding in plastic cassettes
Question Sixteen
In H/E staining, what is the colour of the cytoplasm in well stained tissue.
Blue
Pink
Red
Green
Question Seventeen
The following is the correct orderly phases of wound healing either by first or second intention:
Wound contractin – inflammation – collagen accumulation- Granulation tissue
Granulation tissue – wound contraction-inflammation-collagen accumulation
Inflammation-Granulation tissue-Wound Contraction – Collagen Accumulation
Collagen accumulation – Inflammation-Granulation tissue – Wound Contraction
Question Eighteen
Which of the following represent a malignant tumour:
Leiomyoma
Lipoma
Fibroadenoma
Osteosarcom
Question Nineteen
Immuno-histochemistry (IHC) staining is not useful in:
Primary diagnosis of carcinoma
Characterization of Hormonal response to carcinoma of the breast.
Classification of lymphomas into T and B lymphomas
Identification of invasive carcinoma in the lymph node.
Question Twenty
In staining for microorganism the following is used to stain for H-pylori in the gut:
Foltana stain
Grocott’s stain
Giemsa stain
Periodic acid Shief’s stain
SECTION B: COMPULSORY
Twenty One
Define apoptosis and give examples of apoptosis both in normal and pathological conditions in human.
Twenty Two
Describe systematically the staining process fo tissue using H/E staining.
Twenty Three
Discuss the features of chronic inflammation and possible outcomes.
Twenty Four
Describe steps of acute inflammation following tissue injury.
Twenty Five
List five predisposing (causative) factors to high rates of cancers in Kenya.
Twenty Six
Describe the types of cellular changes in tissue adaptation
SECTION C: ANSWER ANY TWO QUESTIONS (10 MARKS EACH)
Question Twenty Seven
Describe systematically the general procedure staining for cytology using pap staining technique.
Question Twenty Eight
Discuss in detail the mechanism in wound healing by first intention.
Question Twenty Nine
Discuss in details the causes and types of tissue necrosis.
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