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Hml 104: Basic Biochemistry Ii Question Paper
Hml 104: Basic Biochemistry Ii
Course:Bachelor Of Science In Medical Laboratory Science
Institution: Kenyatta University question papers
Exam Year:2010
KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
SUPPLEMENTARY EXAMINATION FOR THE DEGREE OF BACHELOR OF
SCIENCE MEDICAL LABORATORY
HML 104:
BASIC BIOCHEMISTRY II
DATE: Monday, 23rd August, 2010
TIME: 8.00 a.m. – 10.00 a.m.
------------------------------------------------------------------------------------------------------------
INSTRUCTIONS:
SECTION A:
Answer ALL questions.
1.
Describe the possible fates of oxaloacetate in the body.
(5 marks)
2.
a)
Define what purines are.
(2 marks)
b)
List the purines.
(3 marks)
3.
Outline the regulation steps in fatty acid oxidation.
(5 marks)
SECTION B:
Answer only ONE question.
1.
Describe the glycolytic pathway.
(20 marks)
2.
Discuss the urea cycle in various animal classes.
(20 marks)
SECTION C:
Answer ALL questions by ticking on the correct answer. (Each question ½ mark)
Page 1 of 8
1.
The conversion of phosphoend pyruvate is catalyzed by:-
a)
Pyruvate dehydrogenase
b)
Pyruvate kinase
c)
Phesphoply ceromutase
d)
Pyruvate mutase
2.
Which enzyme converts pyruvate to acetyl CoA?
a)
acyl CoA mutase
b)
Pyruvate carboxylase
c)
Pyruvate decarboxylase
d)
Pyruvate dehydrogenase
3.
Consumption of a mean rich in carbohydrates or administration of insulin
increases the amount of all the following except:-
a)
gluco kinase
b)
phesphofructo kinase
c)
glucagons
d)
pyruvate kinase
4.
For oxaloacetate to enter the inner mitochondrial membrane, it is first reduced to:-
a)
Citrate
b)
Malate
c)
Succinate
d)
Oxalate
5.
Which one of the following compounds cannot give rise to the net synthesis of
glucose?
a)
Acetyl CoA
b)
Lactate
c)
Glycerol
d)
Oxaloacetate
Page 2 of 8
6.
Citrate is isomerized to isocitate by:-
a)
Dihydrolipoyl dehydrogenase
b)
Citrate synthase
c)
Aconitase
d)
Phosphofructo kinase
7.
Carbonhydrates with an aldehyde as the most oxidized functional group are
called:-
a)
ketoses
b)
glucose
c)
mannose
d)
aldeses
8.
Which one of the following compounds is not produced from dietary starch by
salivary ? - amylase?
a)
maltose
b)
oligosaccharides
c)
isomaltose
d)
fructose
9.
The form in which most dietary lipids are packaged and exported from the
intestinal mucosal cells is as:
a)
chylomicrons
b)
mixed micelles
c)
free fatty acids
d)
free tracyl glycerol
10.
Which one of the following enzymes is NOT involved in the degradation of total
dietary lipid during digestion?
a)
Gastric lipase
b)
Pancreatic lipase
Page 3 of 8
c)
Lipoprotein lipase
d)
Cholesterol esterhydrolase
11.
Enzymes involved in the synthesis of glycosphingolipids are:-
a)
sulfottransferases
b)
glycosyl transferases
c)
amylases
d)
oxidoreductases
12.
Which one of the following carbohydrates is a ketese sugar?
a)
galactose
b)
fructose
c)
glucose
d)
mannose
13.
Which one of the following is not intermediate or precursor in the synthesis of
herne?
a)
succinyl CoA
b)
porphobilinogen
c)
bilirubin
d)
Gamma – aminolevulinic acid
14.
Which one of the following compounds serves as a receptor for the amino groups
of many amino acids during metabolism
a)
glutamine
b)
alpha – ketoglutarate
c)
asparagines
d)
oxalate
15.
The base thymine is always paired with:-
a)
adenine
Page 4 of 8
b)
guanine
c)
cytosine
d)
thymine
16.
Carbamoyl phesphosphate and ornithine combine to form:-
a)
citrulline
b)
ornithine
c)
argininosuccinate
d)
fumarate
17.
Which of the following is not a component of nucleolides?
a)
pentose sugar
b)
phosphate group
c)
nitrogenous base
d)
dihydroxyacelone
18.
Old red blood cells are removed from circulation and degraded by the:-
a)
liver
b)
gall bladder
c)
spleen
d)
kidney
19.
One of the following is not a biological cause for the synthesis of keto acides:-
a)
post exercise activities
b)
orcreating
c)
starvation
d)
diabetes mellitus
20.
Fatty acyl glycerols:-
a)
act very rich in energy resource
b)
form integral components of lipids
Page 5 of 8
c)
are isomeric
d)
are building blocks of phospholipids and glycolipids synthesis.
21.
Epinephrine may initiate one of the following processes in the body:-
a)
cause fever
b)
act as a broncho-constrictor
c)
increase the heart rate
d)
constrict blood vessels supply to the muscles
22.
One of the following is not a stage in beta oxidation:-
a)
activation of fatty acids in cytosol
b)
transport of fatty CoA into mitochondria
c)
breakage of two high energy bonds to produce Amp
d)
transport of fatty acyl CoA out of the mitochondria via the carnitine
shuttle.
23.
Which of the following statements is not a characteristic of carbolic reaction?
a)
they serve to generate energy
b)
they produce NADH or FADH2
c)
they are divergent processes in which a few precursors form a wide variety
d)
glycolysis is an example of a catabolic pathway
24.
Compared to a resting state, vigorously contracting muscles show:-
a)
an increased conversion of pyruvate to lactate
b)
decreased oxidation of pyruvate to CO2 and water
c)
a decreased NADH/NAD+ ratio
d)
decreased levels of fructose 2, 6 – bisphosphate
25.
The first step in the biosynthesis of porphyrins in the condensation of:-
a)
amnolevulinate and succinyl CoA
b)
gycine and succinyl CoA
Page 6 of 8
c)
uroporphyrinogen and aminolevulinate
d)
none of the above.
26.
Surplus dietary amino acids may be converted to:-
a)
kenones and fat
b)
glucose and biomolecules for which they are precursors
c)
proteins and ketones
d)
all of the above
27.
Hyper bilirubinemia may be due to all of the following EXCEPT:-
a)
overproduction of biliverdin
b)
over production of bilirubin
c)
hepatic celhilar damage
d)
hepatic ducts blockage
28.
Which one of the following would be expected in pyruvate kinase deficiency?
a)
increased levels of lactate in the red blood cell
b)
hemolytic anaemia
c)
decreased ratio of ADP to ATP in the red blood cell
d)
decreased hepatic oxidation of glycose
29.
Muscle glycogen cannot contribute directly to blood glucose levels because:-
a)
muscle glycogen cannot be converted to glucose – 6 – phosphate
b)
muscle lacks glucose 6 – phosphatase
c)
muscle contains no glucokinase
d)
muscle lacks phesphoglucoisomenase
30.
Which one of the following compounds is a precursor in the biosynthesis of
cholesterol?
a)
coprostanal
b)
progesterone
Page 7 of 8
c)
lanosterol
d)
cholic acid
Page 8 of 8
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