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Hml 310: Transfusion Ii Question Paper

Hml 310: Transfusion Ii

Course:Bachelor Of Science In Medical Laboratory Science

Institution: Kenyatta University question papers

Exam Year:2010

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
INSTITUTIONAL BASED PROGRAMME (IBP)
EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN
MEDICAL LABORATORY

HML 310: TRANSFUSION II

DATE: Friday 30th April, 2010

TIME: 8.00 a.m – 10.00 a.m

INSTRUCTIONS:
SECTION A
Section A: Short Answer Questions
Attempt ALL the Questions (5 Marks Each)

1.
Write short notes on Histocompatibility Complex
2.
Briefly discuss the disease transmitted by blood transfusions
3.
Give a brief account of human neutrophil antibodies

Section B: Essay Questions
Attempt ONLY ONE question 20 marks each

Section C Multiple Choice Questions
Attempt ALL the Questions (½Mark Each)

1.
The major histocompatibility complex (MHC) is located on

a)
Long arm of chromosome 6

b)
Short arm of chromosome 6

c)
Long arm of chromosome 16

d)
Short arm chromosome 16

e)
None of the above
2.
Regarding class 1 antigen

a)
The classical genes are HLA DR DP HLADQ

b)
Poorly expressed on lymphocytes

c)
Well expressed on Hepatocytes

d)
Encoded proteins are expressed on all nucleated cells

e)
Platelets lack expression

Page 1 of 7

3.
All of the following are transplant antigens EXCEPT

a)
HLA A

b)
HLA B

c)
HLA DR

d)
HLA DQ

e)
HLA HLA DO
4.
HLA class 1 molecules are recognized by

a)
CD3 Lymphocytes

b)
CD 4 Lymphocytes

c)
CD 8 Lymphocytes

d)
CD 10 Lymphocytes

e)
CD 19 Lymphocytes
5.
HLA class II molecules are recognized by

a)
CD3 Lymphocytes

b)
CD4 Lymphocytes

c)
CD8 Lymphocytes

d)
CD 10 Lymphocytes

e)
CD 19 Lymphocytes
6.
Inate immunity is a function of

a)
NK cell

b)
T lymphocytes

c)
B lymphocytes
d)
Both T and B lymphocytes
e)
Basophils
7.
The most widely used molecular method for HLA typing is

a)
Enzymes linked immunoassay

b)
Southern blot analysis

c)
DNA micrroarrays

d)
PCR sequence specific primers

e)
Fluorescent

Page 2 of 7

8.
Graft versus host disease is seen in

a)
Kidney transplant

b)
Liver transplant

c)
Lung transplant

d)
Bone marrow transplant

e)
Skin grafting
9.
Graft versus host disease is due to

a)
Immunocompetent B cells in recipient

b)
Immunocompetent T cells in donor

c)
Immunocompetent NK cells in recipient

d)
Immunocompetent dendritic cells in donor

e)
Immunocompetent most cells in recipient
10.
HLA antibodies in pregnancy are

a)
Most frequency seen in the first pregnancy

b)
Usually in type

c)
IgG in type

d)
Do not fix complemeny

e)
Cause neonatal neutropenia and thrombocytopenia
11.
Febrile transfusion reactions are due to

a)
HLA antibodies

b)
Human neutrophil antibodies

c)
Human neutrophil antibodies

d)
Rhesus antibodies

e)
None of the above
12.
All the following are blood components except

a)
Packed red cells

b)
Fresh frozen plasma

c)
Cryoprecipitate

d)
Platelet concentrates

e)
Dextran

Page 3 of 7

13.
Platelets transfusions are indicated for

a)
Immune thrombocytopenia

b)
Haemophilia A

c)
Haemophilia B

d)
Thromboytopenia in a plastic anaemia

e)
Thrombatic thrombocytopenic purpura
14.
Graft versus Host disease is prevented by the use of

a)
Packed red cells

b)
Washed red cells

c)
Frozen red cells

d)
Buffy coat poor red cells

e)
Irradiated red cells
15.
In Kenya blood is screened for all the following except

a)
HIV I and II

b)
Hepatitis B

c)
Hepatitis C

d)
Syphilis

e)
HTLV I
16.
Transfusion Related Acute lung injury is due to

a)
Human platelet antibodies in the donor

b)
Human red cell antibodies in the recipient

c)
Human neutrophil antibodies in the donor

d)
HLA antibodies in the recipient

e)
Human neutrophil antibodies in the recipient
17.
Fresh frozen plasma

a)
Is indicated for volume replacement in bleeding patients

b)
Is stored at room temperature

c)
Can be frozen again after thawing is not used.

d)
Contains platelets that are viable

e)
Can be used to treat bleeding in patients with liver disease

Page 4 of 7

18.
Autologous transfusion is mainly used for which one of the following clinical
setting.

a)
Elective hip replacement surgery

b)
Emergency caesarian section

c)
Surgery for acute appendicitis

d)
Severe anemia due to malaria

e)
Anaemia in cancer patients
19.
Whole blood is indicated for

a)
Transfusion in elderly patients

b)
Repeated transfusions in chronic anemia patients

c)
Patients with cardiac failure and anaemia

d)
Exchange transfusion in neonates and adults

e)
Patients with burns
20.
Transfusion on one unit of packed red cells will increase.

a)
The haemoglobin by 1g/dl

b)
The haematocrit by 1%

c)
The patient count by 10 x 109/l

d)
The white cell count by 10 x 109/l

e)
The prothrombin time by 10 seconds
21.
All of the following common finding in Acute Lymphocyte Leukemia EXCEP:

a)
Epitaxis

b)
Fever

c)
Marked elevation in WBCs

d)
Gum hypertrophy
22.
In Acute myelocytic leukemia all of the following correct EXCPT:

a)
Bone marrow examination is essential diagnosis

b)
Philadelphia +ve chromosome

c)
More common in adult

d)
It is worse prognosis than chronic myeloid leukemia.

Page 5 of 7

23.
The Philadelphia chromosome observed in which one of the following leukemia:

a)
Chronic myeloid leukemia

b)
Acute Lymphocytic leukemia

c)
Both

d)
Neither
24.
Diagnostic criteria of secondary polycythemia all of the following EXCEPT

a)
Smoking

b)
Renal cyst

c)
A high altitude

d)
Diabetes mellitus
25.
Haemophilia A (factor IIIV deficiency) EXCEPT:

a)
All males with defective gene have hemophilia

b)
It is Autosomal dominant inheritance

c)
50% of daughter’s of hemophilic man are carrier

d)
50% of daughter of hemophilic man are diseased
26.
Thrombocytopenia can be all of the following EXCEPT:

a)
ITP

b)
ALL

c)
AML

d)
Essential thrombocytopenia
27.
Factor for venous thrombosis include all Except:

a)
Immobilization

b)
Estrogen therapy

c)
Anti thrombin III deficiency

d)
Exercise
28.
Which can cause thrombosis?

a)
Liver disease

b)
Thrombocytopenia

c)
Anti phospholipids Syndrome

Page 6 of 7

29.
Hodgkin’s Diseases the most common histological subtype is:

a)
Lymphocytic predominant

b)
Mixed Cellularity

c)
Nodular sclerosing

d)
Lymphocyte depleted
30.
In which of the following Hematological disorders the polymerase chain reaction
is helpful:

a)
Megaloblastic anemia

b)
Hemolytic anemia

c)
Iron deficiency anemia

d)
Hemolytic malignancy
Page 7 of 7

Hml 310: Transfusion Ii Question Paper

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