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Basic Metabolism Ii Question Paper

Basic Metabolism Ii

Course:Bachelor Of Science

Institution: Kenyatta University question papers

Exam Year:2009

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
FIRST SEMESTER EXAMINATION FOR THE DEGREE OF BACHELOR OF
BIOCHEMISTRY/BIOTECHNOLOGY
SBC 200N: BASIC METABOLISM II
DATE: Monday 28th December, 2009 TIME: 11.00 a.m. – 1.00 p.m.
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SECTION A – Answer ALL questions (20 marks each)

1.(a) The oxidation of acetyl-CoA added to isolated, intact mitochondria is
stimulate strongly by carnitine. Using appropriate illustrations explain
why.

(b) Draw the four basic steps in the oxidation of a saturated fatty acid. Show
structures, name enzymes, and indicate where any cofactors participate.

2.(a) Show the reaction in which ammonia is formed from glutamate; include
any required cofactors.

(b) Describe the reactions of the urea cycle. Show structures, name enzymes
and indicate where any cofactors participate.

3. Describe the mechanism for moving acetyl-CoA produced in the mitochondrial
matrix into the cytosol for fatty acid synthesis. Show structures, name enzymes
and indicate where any cofactors participate.

SECTION B – Answer ALL questions (10 marks each)

4. Describe the pathway by which inosinic acid (IMP) is converted to GMP and
AMP. Show structures, name enzymes, and indicate where any cofactors
participate.

5. Describe how ketone bodies are utilized in extra hepatic tissues.

6. (a) There are bacteria for which alanine can serve as the chief energy source;
they oxidize the carbon skeleton of this amino acid, thereby generating
ATP. Describe the first step in alanine degradation; show any cofactors
that participate.

(b) Explain the distinction between glucogenic and ketogenic amino acids in
terms of their metabolic fates.

Basic Metabolism Ii Question Paper

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