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Sbc 103: Basic Metabolism Ii Question Paper
Sbc 103: Basic Metabolism Ii
Course:Basic Metabolism
Institution: Kenyatta University question papers
Exam Year:2009
Section A:
Answer ALL questions in this Section.
1.
Describe the metabolic disorders of histidine metabolism.
(5 marks)
2.
How may the environment cause DNA mutations?
(5 marks)
3.
What are the functions of fatty acids in the body?
(5 marks)
Section B:
Answer only ONE question in this Section.
4.
Describe the degradation of amino acids in the body.
(20 marks)
5.
Discuss the working of the fatty acid elongase system.
(20 marks)
6.
a)
Discuss the various categories of antibiotics that inhibit protein synthesis.
(10 marks)
Page 1 of 8
b)
Describe
the
metabolic
disorders of porphyrin metabolism. (10 marks)
Section C:
Multiple choice questions. Each question is worth ½ mark
Answer ALL the questions.
1.
Which of the following amino acids have their alpha-amino group removed by
dehydratases
1.
histidine
2.
trytophan
3.
serine
4.
glutamine
5.
threonine
a)
1,2
b)
2,4
c)
4,1
d)
3,5
2.
One of the following reactions does not occur in the urea cycle
a)
Formation of carbomoyl phosphate
b)
Transfer of carbomoyl group to ornithine
c)
Condensation of citruline to aspartate
d)
Cyclization of linear tetraprolle
3.
One of the enzymes below is not used in carnitine shuttle system:-
a)
Acyl Co A carnitine transferase I
b)
Acyl Co A carnitine transferase IV
c)
Translocase
d)
Acyl Co A carnitine transferase II
Page 2 of 8
4.
Which of the following answers completes the sentence correctly? Surplus
dietary amino acids may be converted into:
a)
ketone and fat
b)
glucose and biomolecules for which they are precursors
c)
proteins and ketones
d)
all of the above
5.
The conversion of IMP to GMP requires which of the following?
a)
ATP
b)
GTP
c)
Glutamine
d)
NAD
6.
Which of the following is not intermediate or precursor in the synthesis of herne?
a)
gamma-aminolevulinic acid
b)
Bilirubin
c)
Porphobilinogen
d)
Succinly CoA
7.
Which of the following are intermediate in the pathway for the synthesis of both
phenyl alanine and tryptoplan?
a)
Prephenate, shikimate
b)
Anthranilate, chorismate
c)
Shikimate, chorismate
d)
Prephenate, anthranilate
8.
Which of the following reactant and products are involved in the salvage reaction
of purine biosynthesis?
a)
IMP? AMP
b)
IMP? GMP
c)
adenine? AMP
d)
cytosine? ATP
Page 3 of 8
9.
Which of the following is a high energy compound
a)
glycerol
–3-
phosphate
b)
adenosine diphosphate
c)
glucose –1- phosphate
d)
fluctose –6- phosphate
10.
Which of the following answer completes the sentences correctly? Cytosine is a:-
a)
purine base
b)
pyrimidine base
c)
purine nucleoside
d)
pyrimidine nucleoside
11.
One of the following is a non-essential amino acid:-
a)
histidine
b)
lysine
c)
phenyl alanine
d)
glutamic acid
12.
Which of these symptoms occur in patients suffering from classic phenyl
ketonuria
a)
lack of myelinations of nerves
b)
lighter skin and hair colour
c)
hyperactive reflexes
d)
all of the above
13.
Which blotting technique is used for detection of DNA that has been separated
from the mixture of DNA restriction fragment by electrophoresis through an
agarose gel and then transformed nitrocellulose sheet?
a)
Eastern blotting
b)
Northern blotting
c)
Southern blotting
d)
Western blotting
Page 4 of 8
14.
Which of the following statements are correct? Chemically hydrolyzed
oligonucleotides can be used.
a)
As primers of sequencing DNA
b)
To synthesize genes
c)
As probes for hybridization
d)
All of the above are true
15.
Which of the following statement about DNA polymerases are correct?
a)
they add de-oxyribonucleotide units to the 3’-hydroxyl of a primer
b)
they use the template stand to help choose which deoxyribonucleotide unit
to add to the growing DNA chain.
c)
they check the size of an incoming deoxy ribonucleotide triphosphate
(dNTP) to help ensure the correct complementary code choice.
d)
all of the above statement are correct
16.
One of the following statements about release factors is in correct
a)
They recognize terminator tRNAs
b)
They recognize translation stop codons
c)
They cause peptidyl transferase to use water as a substitute
d)
They are two proteins each of which recognizes two mRNA triplet
sequences.
17.
Which of the following statements about DNA application in E.coli is incorrect?
a)
it occurs in the replication fork
b)
it starts at a unique locus on the chromosomes
c)
it uses RNA transciently as a template
d)
it is bi-directional
Page 5 of 8
18.
Which of the following statement about the triacylglcerols stored in adipose tissue
are incorrect?
a)
They are hydrolyzed to form fatty acids and dihydroxyacetone
b)
They are hydrolysed by a lipase that is activated by covalent modification
c)
They can yield a precursor of glucose
d)
They are mobilized by epinephrine or glucagons
19.
Which of the following answers complete the sentence correctly? The removal
of alpha amino groups from amino acids for conversion to urea in animals may
occur by:-
i)
transamination
ii) reductive
amination
iii) oxidative
deamination
iv) transamination
a)
i, iii
b)
iii, iv
c)
iv, I
d)
ii, iv
20.
Which of the following are amino acids does not have an aromatic side chain?
a)
Leucine
b)
Tyrosine
c)
Tryptophan
d)
Phenyl alainine
21.
One of the following reasons does not lead to breakdown of triacylglycols:-
a)
fight
b)
constipation
c)
flight
d)
starvation
Page 6 of 8
22.
Epinephrine may initiate one of the following processes in the body
a)
Increase the heart rate
b)
Cause fever
c)
Constrict blood vessels supply to the muscles
d)
Act as a broncho-constrictor
23.
Which of these enzymes absence or total decrease cause histidinemia?
a)
Histidase
b)
urocanase
c)
transaminase
d)
arginase
24.
some enzymes involves in DNA replication are listed below. Which one is not
involved
a)
DNA polymesase I
b)
DNA polymesase II
c)
DNA ligase
d)
DNA oxidase
25.
Which of these statements does not account for the causes of mutation? Mutation
may arise due to
a)
Spontaneous damage of DNA
b)
Environmental damage of DNA
c)
Cross bleeding of related animal species
d)
Exposure of DNA to high temperatures
26.
Which of the following compounds serves as a receptor for the amino groups of
many amino acids during catabolism?
a)
glutamine
b)
alpha – ketoglutarate
c)
asparagines
d)
oxalate
Page 7 of 8
27.
One of the following is not a biological cause for the synthesis of keto acids
a)
Post exercise activities
b)
Over eating
c)
starvation
d)
Diabetes mellitus
28.
Fatty acyl glycerols:-
a)
act as very rich in energy resource
b)
form integral components of lipids
c)
are isomeric
d)
are building blocks of phosphospholipids and glycolipid synthesis
29.
Which of the following portion of a longer duplex DNA segment are likely to be
recognition sequences of a restriction enzyme?
a)
5’ – AGTC-3’
3’ – TCAG-5’
b)
5-ATCG-3
3’ – TAGC –5’
c)
5’ – ACCT –3’
3’ – TGGA –5’
d)
5’ – AGGT – 3’
3’ – TGCA – 5’
30.
Which of the following doesn’t reverse transcriptase require for the conversion of
single strand RNA into double strand DNA?
a)
all four dNTPs
b)
an RNA template
c)
aprimer
d)
a DNA template
Page 8 of 8
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