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Introduction To Clinical Pharmacology Question Paper

Introduction To Clinical Pharmacology

Course:Bachelor Of Science In Nursing And Public Health

Institution: Kenyatta University question papers

Exam Year:2008

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2008/2009
FIRST SEMESTER EXAMINATION FOR THE DEGREE OF
BACHELOR OF SCIENCE (NURSING & PUBLIC HEALTH)

HNS 210: INTRODUCTION TO CLINICAL PHARMACOLOGY

DATE: __THURSDAY 27TH DECEMBER 2008___ TIME: 8.00 A.M. – 10.00 A.M.

INSTRUCTIONS:

Section A: Multiple choice questions (20 marks)
Answer ALL questions on the answer sheet

Q1.
The following antibodies can be used to cover mainly gram negative bacteria.
Which one does not?
a)
Erythromycin.
b)
Chloramphenicol.
c)
Cefadioxil.
d)
Gentanycin.

Q2.
A 16 year old boy is diagnosed with tuberculosis of the spine. Which of the
following statements is true about his treatment?
a)
His initiation therapy should comprise of 5 drugs streptomycin,
spyrazinamide, ethambutol, isoniazide and nifampisin.
b)
Duration of his therapy should be 8 months 2 months intensive phase and
6 months continuation phase.
c)
His intensive therapy should be 3 drugs – rifompsin, isoniazide, and
pyrazinamide.

1
d)
He should receive 4 drugs including streptomycin, pyrazinamide,
isoniazide, and rifampsin in the initiation phase, followed by 4 months of
rifampsin and isonia zide.

Q3.
Which of the following drugs are contraindicated in children?
a)
Vancomycin.
b)
Piferacillin.
c)
Ciprofloxacin.
d)
Amikacin.

Q4.
The following statements are true regarding drug elimination. Which statement is
false?
a)
Probenocid enhances elimination of penicilins.
b)
Ascorbic acid may enhance the elimination of amphetamines.
c)
Alkalinization fo wine promotes elimination fo salicylates.
d)
Forced diurisis promotes elimination of all rerally secreted drugs.

Q5.
The following statements are true regarding drug metabolism. Which statement is
false?
a)
Phenobarbitone use may lead to warfamin underdose.
b)
Cimetidine is a potent liver enzyme induces.
c)
Lignociane is predominantly eliminated through the liver.
d)
Pifampsin use may lead to contraceptive failure.

Q6.
Which of the following statements is false?
a)
Intramuscular route is contraindicated in patients with thrombocytopenia.
b)
Bublingual administration bypasses the hepatic first pass metabolism.
c)
Topical drugs may lead to systemic toxicity in neonates.
d)
Rectal route is not ideal in the elderly patients.

2
Q7.
The following statements are true regarding drug interactions. Which statement is
false?
a)
Combination of gentamycin and augumentin are desirable in severe
preumonia.
b)
Use of combination antibiotic therapy is important in treatment of neonatal
repsis.
c)
Patients on oral anticragulants should avoid use of antibiotics.
d)
In treatment of brain absess, metronidazole should be part of the therapy.

Q8.
Which of the following statements regarding use of drugs in pregnancy is true?
a)
Renal elimination is reduced due to reduced flurosular filtration rate.
b)
Hepatic blood flow is increased hence faster metabolism of most drugs.
c)
Increase in a depose tissue results in increased tissue binding hence
toxicity.
d)
Oral absorption is faster due to improved blood flow to the gut.

Q9.
The following drugs are matched to their worst toxicities. Which one is not?
a)
Varicomycin – red – man’s syndrome.
b)
Chloramphenicol – gray baby syndrome.
c)
Norfloxacin – bone dysplasis.
d)
Kenamycin – hepatotoxicity.

Q10. The following anti-retroviral agents are linked to their common precautions or
toxicities, which statement is false?
a)
Zidovudine may lead to anaemia due to bone marrow suppression.
b)
Didamosive should be taken on a full stomach.
c)
Lamivudine may be taken without consideration of food intake.
d)
Nevirapine use is associated with skin rashes.

3
Q11. Which of the following statements is true?
a)
Lignoccine elimination may be delayed by co-administration with
hyaluronidase.
b)
Toxicity with cocaine leads to pin-point pupils.
c)
Spinal anaesthesis is commonly associated with hypertension.
d)
Addicts of cocain commonly present with psychologic rather than physical
dependency.

Q12. The following are true statements about antifugal agents. Which one is false?
a)
In tenea corporis, clotrimazole may be administered orally.
b)
In treatment of systemic mycosis, parentral amphofericin B is combined
with fluconazole.
c)
Fluconazole may be used as a simple stat dose in treatment of vaginal
candidiasis.
d)
Griseofulvin is best given on a full stomach.

Q13. Which of the following statements about antimalarial agents is true?
a)
Chloroquine use may be associated with hypotension and hypoglycaemia.
b)
Amodiaguine is administered as a daily dose for 5 days.
c)
Paludine may be used in treatment of moderate malaris infections.
d)
Artemisin-lumefantrin combinations may be administered intravenously in
severe malaris.

Q14. The following is true about antirheumatic agents, which statement is false?
a)
Paracetamol has less potent antiinflamatory effects than analgestic effects.
b)
Common toxicity of ibyoprofen is gastritis.
c)
Methotrexate has potent anti-inflammatory effects.
d)
Chloroquine use is by the capacity to modify the immune responses in the
patient.

Introduction To Clinical Pharmacology Question Paper

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