Metabolic Regulation And Integrated Metabolism Question Paper

Metabolic Regulation And Integrated Metabolism

Course:Bachelor Of Science

Institution: Kenyatta University question papers

Exam Year:2009

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
FIRST SEMESTER EXAMINATION FOR THE DEGREE OF BACHELOR OF
SCIENCE IN BIOCHEMISTRY/BIOTECHNOLOGY
SBC 202: METABOLIC REGULATION AND INTEGRATED METABOLISM

DATE: Thursday 24th December, 2009 TIME: 8.00 a.m. – 10.00 a. m.

SECTION A
Answer any TWO questions (20 marks each)

1.
a)
List five passive glucose transporters and state their Km and tissue
specificity.

[8 marks]
b)
Explain how glucose level, insulin and exercise regulate the function of
these glucose transports in different
tissues.

[12
marks]
2.
a)
Draw the structure of Trp
operon.
[3
marks]
b)
Explain
the
regulation of Trp operon via:
(i)
Trp
repressor
[6
marks]
(ii)
Attenuation
mechanism [8
marks]
c)
Name two other operons which are regulated by the Trp repressor and
state
the
type
of
regulation.
[3
marks]
3.
a)
List any four enzymes of carbohydrate and lipid metabolism which are
regulated via covalent modification.
[2
marks]
b)
Outline the regulation of glycogen phosphorylase activity in the liver and
skeletal
muscle. [5
marks]
c)
Explain the role of the following compounds in regulation of glycogen
phosphorylase activity:
Page 1 of 2

(i)
c-AMP and Ca2+

[3 marks]
(ii)
insulin,
adrenalin
and
glucagon
[8
marks]
(iii)
inhibitor-1
protein

[2 marks]
SECTION B
Answer ALL questions (10 marks each)
4.
a)
Outline the formation of eicosanoids by prostaglandin synthase complex
from
arachidonic
acid. [3
marks]
b)
Explain the regulation of gene expression by eicosanoids and its
precursors via peroxisome proliferators activator receptors [7 marks]
5.
Outline covalent modification of hepatic enzymes of carbohydrate and lipid
metabolisms in well fed state.
6.
a)
Giving an example, outline the mechanism of hormone action with c-AMP
as
a
secondary
messenger.
[7
marks]
b)
Explain the role of insulin in the regulation of c-AMP level.
[3 marks]

……………….
Page 2 of 2

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