Biochemistry 1 Question Paper

Biochemistry 1

Course:Bachelor Of Pharmacy

Institution: Kenyatta University question papers

Exam Year:2009

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
FIRST SEMESTER EXAMINATION FOR THE DEGREE OF BACHELOR OF
PHARMACY

HMB 110:
BIOCHEMISTRY I

DATE: Monday 21st December, 2009

TIME: 11.00 a.m – 1.00p.m
________________________________________________________________________

INSTRUCTIONS:

Answer any FOUR (4) questions
1.
Discuss
uncompetitive
inhibition.
(15
marks)
2.
Describe the reaction schemes to explain bisubstrate reactions occurring via the
ordered
and
ping
pong
mechanisms.
(15
marks)
3.
a)
Describe the Edman degradation process and the ninhydrin reaction of
amino
acids.
(10
marks)

b)
Give the structure of:
i)
Glucogen

(2
marks)

ii)
D-erythrose

(1 mark)
iii)
Phosphatidylcholine

(1
mark)
iv)
Phosphatidylserine

(1
mark)
4.
a)
Draw a structure of a pentapeptide that contains an aliphatic R- group,

aromatic R- group, an alcohol R- group and any other amino acids.

(5 marks)

b)
Identify each residue in your peptide, by name standard abbreviations and
according
to
class.
(5
marks)

c)
Identify five uses of nucleoside
triphosphate.
(5
marks)

Page 1 of 2

5.
a)
One nucleotide of NADH in the cytosol enters the mitochondrion

respiratory chain via glycerol phosphate shuttle. How many molecules of

ATP will it form? Clearly explain your answer using the chemosmotic
theory.

b)
Write the reactions of triacylglycerol hydrolysis in adipose tissue and
skeletal muscle.
6.
How is the model proposed by Singer and Nicholson pivotal to our current
understanding of the organization of membrane lipids?

(15 marks)
7.
a)
With a relevant example, show how acidic buffers maintain the pH of a

solution at a relatively constant value.
b)
How do the open chains of glucose and fructose undergo structural
transformation to ring forms?
Page 2 of 2

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