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Bioc 307: Pharmaceutical Biochemistry Question Paper

Bioc 307: Pharmaceutical Biochemistry

Course:Bachelor Of Science

Institution: Laikipia University question papers

Exam Year:2017

LAIKIPIA UNIVERSITY

UNIVERSITY EXAMINATIONS
2016/2017 ACADEMIC YEAR
THIRD YEAR EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE
BIOC 307: PHARMACEUTICAL BIOCHEMISTRY

STREAM: B.SC (BIOC) TIME: 2 HRS
DAY: FRI (11:30 A.M -1:30 P.M) DATE: 23/6/2017

THIS QUESTION PAPER CONSISTS OF THREE(3) PAGES. PLEASE DO NOT OPEN UNTIL THE INVIGILATOR SAYS SO.

(LAIKIPIA UNIVERSITY IS ISO 9001.2008 CERTIFIED)
VISION: A UNIVERSITY FOR VALUED TRANSFORMATION OF SOCIETY
MISSION: TO SERVE STUDENTS AND SOCIETY THROUGH RESEARCH, EDUCATION, SCHOLARSHIP, TRAINING, OUTREACH AND CONSULTANCY

PAGE 1 OF 3

INSTRUCTIONS: ANSWER ALL QUESTIONS IN SECTION A AND ONLY ONE QUESTION IN SECTION B.

SECTION A:
1. a.) Define the following terms:
i.) Antibiotic (2 Marks)
ii.) Contra-indication (2 Marks)
iii.) Combined Therapy (2 Marks)

b.)Distinguish between the following terms:
i.) Drug abuse and drug misuse (2 Marks)
ii.) Bacteriocidal and bacteriostatic antibiotics (2 Marks)

2.) Using examples, explain the basis of classification of Cephalosporins. (8 Marks)

3.) Compare and contrast between Penicillins and Cephalosporins in terms of :
i.) Chemical structure (4 Marks)
ii.) Spectrum of activity (3 Marks)
iii.) Clinical indications (3 Marks)

4.) Explain the following:
i.) Basis of selective toxicity in beta lactam antibiotics (2 Marks)
ii.) Basis of combining Amoxycillin and Clavulanic acid in therapy (2 Marks)
iii.) Doxycycline should not be taken with milk (2 Marks)
iv.) Minocycline is contraindicated in pregnancy and infants (2 Marks)

5.) Describe the mechanism of action of Doxycycline (6 Marks)

(PAGE 2 OF 3)

6.) Write explanatory notes on the following:
i.) Indications of Ciprofloxacin (4 Marks)
ii.) Adverse drug reactions of Streptomycin (4 Marks)

SECTION B

7.) Describe the mechanism of resistance in any four classes of antibiotics (20 Marks)
8.) Discuss the classification, mechanism of action, pharmacokinetics, adverse reactions, indications and contraindications of Fluoroquinolones (20 Marks)

(PAGE 3 OF 3)

Bioc 307: Pharmaceutical Biochemistry Question Paper

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