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Bioc 301: Medical Biochemistry Question Paper

Bioc 301: Medical Biochemistry

Course:Medical Laboratory Sciences

Institution: Kenya Methodist University question papers

Exam Year:2012

KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012(DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY SCIENCES
UNIT CODE : BIOC 301
UNIT TITLE : MEDICAL BIOCHEMISTRY
TIME : 3HOURS

INSTRUCTIONS: Answer ALL Questions in ALL Sections
SECTION A
QUESTION ONE
In glycolysis which enzyme is required for the conversion of glucose to glucose -6- phosphate
A. Glucokinase
B. Phosphofructokinase
C. Phosphoglyceromutase
D. Pyruvate kinase
QUESTION TWO
Biosynethesis of glucose from other sources is known as
A. Glycolysis
B. Glycogenolysis
C. Gluconeogenesis
D. Glycogenesis
QUESTION THREE
Which hormone is produced by the advenal cortex
A. Thyrotropin
B. Cortisol
C. Parathyroid hormone
D. Vasopressin
QUESTION FOUR
Which of the following is a water soluble vitamin
A. Vitamin A
B. Folic acid
C. Vitamin D
D. Vitamin E
QUESTION FIVE
Mary had a urinary tract infection caused by proteus species. Which analyte in urinalysis could confirm this
A. Glucose
B. Proteins
C. Urobilinogen
D. Nitrites
QUESTION SIX
Purine metabolism disorders are characterized by elevated levels of:
A. Lipids
B. Uric acid
C. Alkaline phosphatase
D Urea
QUESTION SEVEN
Mrs Smith had irregular menses was sweating a lot and frequently suffered from constipation which hormone deficiency could lead to this
A. Cortisol
B. Thyroxine
C. Parathyroid
D. Testosterone
QUESTION EIGHT
Which of the following hormones has no effect on carbohydrate metabolism
A. Insulin
B. Cortisol
C. Thyroxine
D. Progesterone
QUESTION NINE
Of the following enzymes, which one is the odd one out.
A. Arginase
B. Argininosuccinate lyase
C. Pyruvate dehydrogenase
D. Orinithine transcarbomoylase
QUESTION TEN
Which of the following is not a ketone body?
A. Acetoacetate
B. Acetoacetyl co A
C. ß hydroxybutyrate
D. Acetone
QUESTION ELEVEN
Elevated levels of glucose in urine are not seen in cases of
A. Diabetes insipidus
B. Brittle diabetes
C. Diabetes mellitus
D. Gestational diabetes
QUESTION TWELVE
Which process in carbohydrate metabolism is the main source of NADH and FADH2
A. Glycolysis
B. Electron transport chain
C. TCA cycle
D. Oxidative phosphorylation
QUESTION THIRTEEN
Lipid oxidation mainly uses the substrate
A. Malonyl CoA
B. Aceto acetyl coA
C. Acetyl coA
D. Carbamoyl phosphate
QUESTION FOURTEEN
Amino acids that give rise to a net production of pyruvate or TCA cycle intermediates are known as
A. Essential amino acids
B. Glucogenic amino acids
C. Ketogenic amino acids
D. Non-essential amino acids
QUESTION FIFTEEN
Which is the odd one out?
A. Galactosemia
B. Lactose intolerance
C. Lysosomal disease
D. Diabetes mellitus
QUESTION SIXTEEN
The type of metabolism that deals with the breakdown of materials is known as
A. Amphibolism
B. Catabolism
C. Exobolism
D. Anabolism.
QUESTION SEVENTEEN
The end product of aerobic glycolysis is
A. Glucose
B. Glyceraldehde -3- phosphate
C. Pyruvate
D. Lactate.
QUESTION EIGHTEEN
It is a metabolism disorder characterized by elevated levels of sphengolipids in the brain. Which disorder is this
A. Niemann`s disease
B. Tay-sach`s disease
C. Galactosemia
D. Hurler`s syndrome.
QUESTION NINETEEN
Fatty acid oxidation occurs in the
A. Cytoplasm
B. Mitochondria
C. Lysosome
D. Nucleus
QUESTION TWENTY
Which vitamin is crucial for night vision
A. Folic acid
B. Vitamin C
C. Nicotinic acid
D. Vitamin A
SECTION B
QUESTION ONE
What is the biological importance of lipids? (5marks)
QUESTION TWO
a) What are the functions of nicotinic acid in the body? (3marks)

b) State clearly the symptoms of nicotinic acid deficiency. (3marks)

QUESTION THREE
Differentiate between:
a) Deamination and transmination (3marks)

b) IDDM and NIDDM (3marks)

c) Fatty acid oxidation and fatty acid synethesis. (3marks)
QUESTION FOUR
What is the clinical significance of ketogenesis. (3marks)
QUESTION FIVE
Name THREE conditions that are caused by errors in purine metabolism.
(3marks)
QUESTION SIX
a) What is the main buffering system in the body? (2marks)

b) Explain how it works. (8marks)
SECTION C
QUESTION ONE
Clearly explain how the following symptoms come about in diabetes mellitus.
(20marks)
Polydipsia
Glycosuria
Retinopathy
Lipemia
Delayed would healing
QUESTION TWO
a) Name THREE disorders due to errors in lipid metabolism clearly stating how they come about. (10marks)

b) Name THREE disorders due to errors in carbohydrate metabolism clearly stating how they come about. (10marks)

Bioc 301: Medical Biochemistry Question Paper

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