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Dicm 225: Pharmacology &Amp; Therapeutics Ii Question Paper
Dicm 225: Pharmacology &Amp; Therapeutics Ii
Course:Pharmacy
Institution: Kenya Methodist University question papers
Exam Year:2012
KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : PHARMACY
UNIT CODE : DICM 225
UNIT TITLE : PHARMACOLOGY & THERAPEUTICS II
TIME : 3HOURS
INSTRUCTIONS: Answer ALL Questions
Section A contains multiple choice questions, answer T for True and F for False.
A correct answer earns 1 one mark, an incorrect answer earns negative one
Section B contains short answer questions and Section C contain essay questions.
SECTION A MULTIPLE CHOICE QUESTIONS (40marks)
QUESTION ONE
The following statements refer to sedative- hypnotics
A. A sedative is a drug that causes sleep
B. A hypnotic is a drug that facilitates sleep
C. A small dose of a sedative causes hypnosis
D. A small dose of a hypnotic causes sedation.
QUESTION TWO
Barbiturates used as general anesthetics
A. Phenobarbitone
B. Pentobarbitone
C. Thiopentone
D. Amylobarbitone
QUESTION THREE
Local anesthetics block
A. K+ channels
B. Ca2+ channels
C. Na+ channels
D. Cl- channels
QUESTION FOUR
In dental surgery, adrenaline is combined with the following drugs
A. Procaine
B. Lidocaine
C. Butocaine
D. Procainamide
QUESTION FIVE
Trophic hormones from pituitary gland
A. Prolactin
B. Luteinizing hormone
C. Growth hormone
D. Follicle stimulating hormone
QUESTION SIX
Causes of diabetes mellitus type 1
A. Reduced production of insulin by B-cells
B. Destruction of B-cells
C. Auto digestion of islets of Langerhans
D. Autoimmune disease affecting B-cells
QUESTION SEVEN
Diabetes ketoacidosis occur in patients with
A. Diabetes mellitus Type I
B. Diabetes mellitus Type II
C. Gestational diabetes mellitus
D. In both (a) and (b) above
QUESTION EIGHT
Antithyroid drugs
A. Carbimazole
B. Methimazole
C. Propylthiouracil
D. Mebendazole
QUESTION NINE
Drugs not suitable for patients with liver function impairment
A. Prednisone
B. Prednisolone
C. Enalapril
D. Hydrocortisone
QUESTION TEN
Drugs with mainly anti-flammatory action
A. Fludrocortisone
B. Budenisone
C. Beclomethasone
D. Betamethasone
QUESTION ELEVEN
The following are effects of morphine
A. Dysphoria
B. Stimulation of respiratory centre
C. Depression of cough reflex centre
D. Stimulation of chemoreceptor trigger zone.
QUESTION TWELVE
Alpha-adrenoceptor blockers may be used in the treatment of
A. Hypotension
B. Hypertension
C. Asthma
D. Peripheral vascular disease
QUESTION THIRTEEN
A potentially dangerous side effect of propranolol which constitutes a contraindication is its clinical use in suspectible patients is the induction of
A. Hypertension
B. Hypersensitivity
C. Asthma
D. Arrhythmias
QUESTION FOURTEEN
Anticoagulants that are active in vivo only
A. Heparin
B. Warfarin
C. Sodium citrate
D. Potassium citrate
QUESTION FIFTEEN
Anti-anemic drugs
A. ferrous salt
B. Iron dextran
C. Hyroxocobalamin
D. folic acid
QUESTION SIXTEEN
A patient on warfarin is advised to consume some foods with caution.
A. Spinach
B. Beans
C. Cauliflower
D. Carrots
QUESTION SEVENTEEN
When a patient experiences an angina attack that does not respond to first and second glyceryl trinitrate tablets, it suggests that the patient
A. Maybe in the early stages of myocardial infarction
B. need administration of isosorbide dinitrate
C. need to be rushed to hospital.
D. need the third and fourth tablets of nitroglycerine.
QUESTION EIGHTEEN
Mymetrial relaxants include
A. Salbutamol
B. Ergometrine
C. Ritodrine
D. Magnesium sulphate
QUESTION NINETEEN
Alkalyting agents in ant-neoplastic theraphy
A. Cyclophosphamide
B. Lomustine
C. Vinblastine
D. Doxorubicin
QUESTION TWENTY
Used in pregnant women to prevent HIV transmission from mother to child
A. Stavudine
B. Effiverenz
C. Nevirapine
D. Acyclavor
SECTION B (40marks)
QUESTION TWENTY ONE
In the management of diabetes mellitus I "human insulin" is administered. However this drug is obtained from laboratory micro-organism. Explain how this is possible. (4marks)
QUESTION TWENTY TWO
Explain:
Why heparin sodium is given to initiate therapy of oral anti-coagulants
(4marks)
Sedation is a common side effect of chlorpheniramine.
(4marks)
QUESTION TWENTY THREE
Differentiate between
Physiology and psychological drug dependence.
(4marks)
Stable chronic angina and unstable an angina.
(4marks)
QUESTION TWENTY FOUR
a) State FOUR advantages of combining drugs in the management of diseases and disorders. (4marks)
b) Explain why anti-depressants are not administered to breast feeding mothers. (2marks)
QUESTION TWENTY FIVE
a) Give FOUR reasons why benzodiazepines are preferred to barbiturates as sedative-hypnotics. (4marks)
b) Describe the mode of action of combined oral contraceptive pill. (6marks)
QUESTION TWENTY SIX
Describe the mode of action of thiazide diuretics in the management of hypertension. (4marks)
SECTION C (40marks)
QUESTION TWENTY SEVEN
Discuss the adverse drug reactions that are associated with long term therapy of glucocortion steroids. (20marks)
QUESTION TWENTY EIGHT
a) Classify drugs used in the management of bronchial asthma. Give appropriate examples in each class. (10marks)
b) Describe the mode of action of one drug from each named in a) above.
(10marks)
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