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Dpht 027: Pharmacology &Amp; Therapeutics I Question Paper

Dpht 027: Pharmacology &Amp; Therapeutics I

Course:Pharmacy

Institution: Kenya Methodist University question papers

Exam Year:2012

KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : PHARMACY
UNIT CODE : DPHT 027
UNIT TITLE : PHARMACOLOGY & THERAPEUTICS I
TIME : 3HOURS

INSTRUCTIONS: Answer ALL Questions.
This paper consists of THREE Sections A, B and C
Section A contains Multiple choice Questions,
Section B consists of Short Answer Questions and Section C contains essay questions
SECTION A (20marks)
QUESTION ONE
Which of the following is a miotic drug?
A. Atropine
B. Homatropine
C. Pilocarpine
D. Tropicamide
QUESTION TWO
An anticoagulant which acts in vivo only is
A. Heparin
B. Warfarin
C. Sodium citrate
D. Potassium citrate
QUESTION THREE
Which drug prolongs duration of local anaesthetics such as lignocaine?
A. Adrenaline
B. Terbutaline
C. Pilocarpine
D. Nizatidine
QUESTION FOUR
A drug that is an irreversible inhibitor of cyclo-oxygenase enzyme system is
A. Paracetamol
B. Aspirin
C. Mefenamic acid
D. Ibuprofen
QUESTION FIVE
Antidiolinesterase used in the treatment of atropine poisoning is
A. Pyridostigmine
B. Distigmine
C. Physostigmine
D. Neostigmine
QUESTION SIX
The following groups of drugs are used in the management of hypertension except
A. Thiazides
B. Beta-blockers
C. Calcium channel blockers
D. muscarinic blockers
QUESTION SEVEN
Plasma protein binding of drugs confers the drugs that bind the following characteristics except
A. have a low volume of distribution
B. longer duration of action
C. rapid excretion through the kidney
D. are not affected by glmenular filtration.
QUESTION EIGHT
Pre-systemic metabolism of drugs takes place mainly in the
A. Gastrointestinal tract.
B. Blood plasma
C. Kidney
D. Liver.
QUESTION NINE
A drug that blocks conversion of paraminobenzoic acid into dihyfrofolate is
A. Dapsone
B. Sulphanimide
C. Trimethoprim
D. Pyramethamine
QUESTION TEN
A drug that exerts its therapeutic effect through its chemical properties is
A. Barium sulphate
B. Magnesium hydroxide
C. Magnesium sulphate
D. Cimetidine
QUESTION ELEVEN
A fibrinolytic drug
A. Hexokinase
B. Streptokinase
C. Cholinesterase
D. Phosphokinase
QUESTION TWELVE
The effect of warfarin can be reduced by
A. Aspirin
B. Cimetidine
C. Carbenicillin
D. Vitamin K
QUESTION THIRTEEN
A patient on hyosine N-butylbromide for a long time may develop
A. increased gastrin secretion
B. diarrhoea
C. constipation
D. heart burn
QUESTION FOURTEEN
Ganglion blocker
A. Trimethaphan
B. Dextromethophan
C. Trypophan
D. Levorphan.
QUESTION FIFTEEN
The most appropriate drug to use in the treatment of peptic ulcer is
A. Diphenhydramine
B. Chlorpheniramine
C. Terfenadine
D. Ranitidine
QUESTION SIXTEEN
Which of the antithyroid drugs is suitable for use in pregnancy and lactation?
A. Carbimazole
B. Methimazole
C. Propylthiouracil
D. Radioactive iodine
QUESTION SEVENTEEN
The following drugs depress central nervous system to varying degrees except
A. ethanol
B. phenobarbitone
C. diazepam
D. paracetomol
QUESTION EIGHTEEN
Antimuscarinic that is suitable in the management of Parkinson disease is
A. Atropine
B. Scopolanine
C. Benzhexol
D. Ipratroprium
QUESTION NINETEEN
Anti-emetic drug
A. Chlopropamide
B. Metoclopramide
C. Butamide
D. Niclosamide
QUESTION TWENTY
The following drugs are sulphoyly ureas except
A. Glibenclamide
B. Gliclizide
C. Tolbutamide
D. Metformin
SECTION B ESSAY QUESTIONS (25marks)
Explain why the following statements are true Qn 21-23
QUESTION TWENTY ONE
Aspirin is contraindicated in patients on oral anticoagulant therapy with warfarin. (4marks)
QUESTION TWENTY TWO
Milk and its products should be avoided by patients on tetracycline therapy.
(4marks)
QUESTION TWENTY THREE
In severe bacterial infection, there is need for a loading dose and a maintaince dose. (4marks)
QUESTION TWENTY FOUR
State SIX considerations that a clinician must take into account while deciding on the appropriate route of drug administration to a specific patient. (6marks)
QUESTION TWENTY FIVE
Explain the rationale for combining atropine and phenoxylate in the treatment of diarrhea. (4marks)
QUESTION TWENTY SIX
State THREE therapeutic uses of beta adrenoceptor blockers. (3marks)
SECTION C
QUESTION TWENTY SEVEN
Discuss the adverse effects associated with long-term use of glucocorticoids.
(10marks)
QUESTION TWENTY EIGHT
Write an account on drugs that are used in the management of peptic ulcer diseases under the following sub-heading:
Classification and one example in each class
Mode of action for drugs representing any FIVE classes. (15marks)

Dpht 027: Pharmacology &Amp; Therapeutics I Question Paper

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