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Dpht 030: Pharmaceutics Ii Question Paper
Dpht 030: Pharmaceutics Ii
Course:Pharmacy
Institution: Kenya Methodist University question papers
Exam Year:2012
KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : PHARMACY
UNIT CODE : DPHT 030
UNIT TITLE : PHARMACEUTICS II
TIME : 3HOURS
INSTRUCTIONS: Answer ALL Questions in ALL Sections
SECTION A
QUESTION ONE
Which one is (are) appropriate when preparing injections for patient use?
Work within 6 inches of the HEPA filler
Use a vertical laminar flow hood
Work in an area at least 6 inches from the edge of the bench.
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. I, ii and iii only
QUESTION TWO
Which of the following agents can disinfect a laminar flow-hood?
Alcohol 70%
Acetone
Betadine
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION THREE
Which of the following are/is the key ingredients in eye drops?
Active ingredient
Antioxidants
Buffers
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION FOUR
Which of the following are the key ingredients in an injection?
Buffers
Isotonizing agents
preservatives
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION FIVE
Which of the following is a suitable diluents for a single dose injection?
A. Bacteriostatic water for injection
B. D5 W injection
C. Normal saline injection
D. normal saline
E. Sterile water for injection
QUESTION SIX
Which of the following will form aprecipitale when added to normal saline?
A. diazepam 20mg
B. Folic acid 1mg
C. furosexide 40mg
D. gentamicin 20mg
E. Succincycholine chloride 100mg
QUESTION SEVEN
Which of the following solutions are compatible when added to 500 ml of D5w?
Thiamine Hcl 20cmg
Potassium chloride
Chlorothiazide sodium
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION EIGHT
What role does potassium phosphate play in injection preparations? It acts as
A. a buffer
B. antioxidant
C. source of potassium
D. stabilizer
E. source of phosphorus
QUESTION NINE
The role of starch in a tablet is to act as a
binder
disintegrant
lubricant
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION TEN
Which of the following types of tablets coatings is used to protect it from the effect of gastric acid?
enteric
film
sugar
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION ELEVEN
Which of the following is not used primarily as a diluent in tablet formulations?
A. Magnesium stearate
B. Dicalcium phosphate
C. lactose
D. mannitol
E. Starch
QUESTION TWELVE
Which of the following statements is likely to be correct in respect to oral liquid dosage forms?
the liquid product will have stability
the liquid product is more economical to manufacture
the liquid product is likely to be absorbed faster.
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION THIRTEEN
Which one of the following may be used as a chelating agent?
A. Absorbic acid
B. hydroquinone
C. Adetate
D. Sodium bisulfile
E. Fluorescein sodium
QUESTION FOURTEEN
The process of grinding a substance to a very fine powder is termed
A. levigation
B. sublimation
C. trituration
D. pulverization
E. maceration
QUESTION FIFTEEN
The usual expiration date that should be placed on a parenteral admixture prepared in a hospital is
A. 1 hour
B. 24 hours
C. 48 hours
D. 72 hours
E. 1 week
QUESTION SIXTEEN
Eye drops that are isotonic with larchrmal fluid have an esmolarity of approximately how many mosm/L?
A. 20
B. 40
C. 50
D. 150
E. 300
QUESTION SEVENTEEN
Which of the following injectables is (are)not isotonic with human RBCs (Red Blood Cells?
D50W
NS
D5N/NS
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION EIGHTEEN
Which of the following vitamins do not possess antioxidant properties?
Ascorbic acid
Ergocalciferol
Pantothenic acid
A. i only
B. iii only
C. i and ii only
D. ii and iii only
E. i, ii and iii
QUESTION NINETEEN
Parenteral products with an osmotic pressure higher than that of blood or 0.9% sodium chloride are referred as
A. Isotonic solutions
B. Hypertonic solutions
C. Iso-osmotic solutions
D. Neutral solutions
QUESTION TWENTY
Disadvantages of chlorobutol in germicide solution include
heat instability
instability at alkaline PH
Loss of polency in the presence of air
A. i only
B. ii only
C. i and ii only
D. i, ii and iii only
E. ii and iii only
SECTION B
QUESTION ONE
Explain the difference between hypertonic and hypotonic solutions. (5marks)
QUESTION TWO
What is the main difference between a gauge size 15 and gauge size 21 needle?
(5marks)
QUESTION THREE
Explain what physical incompatibilities are. (5marks)
QUESTION FOUR
What are the key components of good manufacturing practices (GMP) of parenteral products? (5marks)
QUESTION FIVE
Explain what is process validation. (5marks)
SECTION C
QUESTION ONE
Explain the difference between dry heat sterilization and moist sterilizations.
(10marks)
QUESTION TWO
Indicate the key consideration in selecting a container for a parenteral product.
(10marks)
QUESTION THREE
Outline the key procedures for preparing eye drops. (10marks)
QUESTION FOUR
Indicate the key qualities of eye drops. (10marks)
QUESTION FIVE
Describe FIVE physical hazards of parenteral drug therapy. (10marks)
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