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Mlsc 407:Histopothology And Cytoplogy Question Paper
Mlsc 407:Histopothology And Cytoplogy
Course:Masters In Medical Laboratory
Institution: Kenya Methodist University question papers
Exam Year:2012
KENYA METHODIST UNIVERSITY
END OF 2''ND ''TRIMESTER 2012 (Evening) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : PHARMACY
UNIT CODE : MLSC 407
UNIT TITLE : HISTOPATHOLOGY AND CYTOLOGY
TIME : 3HOURS
INSTRUCTIONS: Answer ALL Questions in Section A and B and ONE Question in Section C Write answers in the answer booklet provided
SECTION A (MULTIPLE CHOICE QUESTIONS (20MARKS) )
QUESTION ONE
Which one of the following terms refers to study of diseases and injury?
A. Pathogenesis
B. Pathology
C. Morphology
D. Clinical significance
QUESTION TWO
Which of the following refers to cells death due to infection?
A. Necrosis
B. Apoptosis
C. Ischeamia
D. Infarction
QUESTION THREE
The dead cells in necrosis assume following changes by fragmentation of nuclei material
A. Karyolysis
B. Pyknosis
C. Gangrenous
D. Karryorrhexis
QUESTION FOUR
The following cellular adaptation is characterized by change from one adult cell to another.
A. Atrophy
B. Hyperplasia
C. Hypertrophy
D. Metaplasia
QUESTION FIVE
Fat deposition accumulation in tissue is referred to as
A. Steatosis
B. Xathomas
C. Anthracosis
D. Haemosederosis
QUESTION SIX
The following causes metastatic calcification except
A. Areas of necrosis
B. Destruction of bone
C. Vitamin D abnormalities
D. Hyperperparathyroidism
QUESTION SEVEN
Chronic inflammation is characterized by all of the following except
A. Vascular changes
B. Infiltration of monocytes
C. Tissue destruction
D. Repair
QUESTION EIGHT
Which of the following cells are cells of chronic inflammation response?
A. Neutrophils
B. Basophils
C. Oesinophils
D. Lymphocytes
QUESTION NINE
Which one of the following represent the correct events in acute inflammation?
A. Margination- Rolling- Adhesion- Transmigration
B. Transmigration – Adhension- rolling - migration
C. Adhesion – Rolling – Margination - Transmigration
QUESTION TEN
The following is/an outcome of acute inflammation
A. Granulomatosus formation
B. Abscess formation
C. Scarring
D. Fibrosing
QUESTION ELEVEN
Grocott`s stain is preferred for tissue demonstration for the following
A. Spirochaetes
B. Elastic fibres
C. Mucins (H bags)
D. Fungal elements
QUESTION TWELVE
Prusian blue stain impregnation can demonstrate one of the following in tissue staining.
A. DNA
B. Reticulin fibres
C. Melanin
D. Ferric salts
E. Mitochondria
QUESTION THIRTEEN
Acute inflammation is mostly characterized by one of the following
A. Vascular changes
B. Infiltration of monocytes
C. Tissue destruction
D. Repair
QUESTION FOURTEEN
The specimen after operating theatre are normally fixed in one of the following
A. In saturated ethyl ether
B. 100% xylene
C. in 40% formal saline
D. in 10% formaline
QUESTION FIFTEEN
In tissue processing for microtomy which is first step after trimming of the specimen.
A. Staining with haemotoxylin and eosin
B. Dehydration
C. Hydration
D. Embedding
QUESTION SIXTEEN
In H/E staining, what is the colour of the nuclei in well stained tissue?
A. Blue
B. Pink
C. Red
D. Green
QUESTION SEVENTEEN
The following is the correct orderly phases of wound healing either by first or second intention
A. Wound contraction- inflammation – collagen accumulation – Granulation
tissue.
B. Granulation tissue – wound contraction – inflammation – collagen
accumulation
C. Inflammation – Granulation tissue – wound contraction – collagen
accumulation.
D. Collagen accumulation – inflammation – Granulation tissue – would contraction.
QUESTION EIGHTEEN
Which of the following represent a benign tumour
A. Leiomyoma
B. Fibromyosarcoma
C. Fibrosarcoma
D. Osteosarcoma
QUESTION NINETEEN
Immunohistochemistry staining is useful in
A. Primary diagnosis of carcinoma
B. Diagnonis of benign tumor only
C. Classification of lymphomas in to T and B lymphomas
D. Identification of organisms in the tissue.
QUESTION TWENTY
In staining for microorganisms the following is used to stain for entamoeba histolytica in the gut.
A. Foltana stain
B. Grocott`s stain
C. Giemsa stain
D. Periodic acid shief`s stain
SECTION B ( SHORT ANSWER QUESTIONS, ANSWER ALL QUESTIONS 30MARKS)
QUESTION TWENTY ONE
Discuss the causes of cell injury and give example of each. (5marks)
QUESTION TWENTY TWO
Describe systematically the general tissue processing ready for microtomy.
(5marks)
QUESTION TWENTY THREE
Discuss the features of acute inflammation and possible outcomes. (5marks)
QUESTION TWENTY FOUR
Describe the steps of wound healing by first intention. (5marks)
QUESTION TWENTY FIVE
List FIVE cellular abnormalities of benign as compared to malignancy lesions.
(5marks)
QUESTION TWENTY SIX
Outline the fine needle procedure of a breast mass. (5marks)
SECTION C ( LONG ANSWER QUESITONS, ANSWER ANY TWO QUESTIONS 20MARKS)
QUESTION TWENTY SEVEN
Describe systematically the general procedure for staining in cytology using pap smear technique. (10marks)
QUESTION TWENTY EIGHT
Discuss in detail the mechanism in chronic inflammation and the outcomes.
(10marks)
QUESTION TWENTY NINE
Define apoptosis and give examples of apoptosis both in normal and pathological conditions in human. (10marks)
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