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Mbio 205:Advanced Microbiology Question Paper

Mbio 205:Advanced Microbiology

Course:Medical Laboratory

Institution: Kenya Methodist University question papers

Exam Year:2012

KENYA METHODIST UNIVERSITY

END OF 3''RD ''TRIMESTER 2012 (DAY) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY SCIENCES
UNIT CODE : HSCI 205/MBIO 205
UNIT TITLE : ADVANCED MEDICAL MICROBIOLOGY
TIME : 2 HOURS

INSTRUCTIONS:

Answer ALL Questions in Section A, and B and ONE Questions in

Section C

SECTION A

QUESTION ONE

Which of the groups listed below have cell walls?

Algae
Mycoplasmas
Gram-positive bacteria
Fungi
Protozoans

QUESTION TWO

Which of the following statements is CORRECT?

All bacteria have peptidoglycan in their walls
All fungi have chitin in their walls.
All algae have cellulose in their cell walls.
All protozoans have protein in their cell walls.
All bacteria have a capsule.

QUESTION THREE

Each of the following organisms is an important cause of urinary tract infections except?

Klebsiella pneunoniae
Escherichi coli
Bacteroides fragilis
Porteus mirabilis
Chlamydia

QUESTION FOUR

Each of the following agents is a recognized cause of diarrhea except

Clostridium perfringens
Vibrio cholerae
Enterococus faecalis
Escherichia coli
Clostridium difficile.

QUESTION FIVE

A 30 year old woman has non bloody diarrhea for the last 14 hours. Which of the following organisms is least likely to cause this illness?

Streptococcus pyogenes
Clostridium difficile
Shigella dysenteriae
Salnonella enteritidis
Vibrio cholera

QUESTION SIX

Which of the following diseases is best diagnosed by serologic means?

Pulmonary tuberculosis
Gonorrhea
Actinomycosis
Q-fever
Pneumonia

QUESTION SEVEN

Each of the following statements concerning gram stain is correct EXCEPT

Escheriohia coli stains pink because it has a thin peptidoglycan layer.
Streptococcus pyogenes stains blue because it has a thick peptidoglycan layer.
Mycoplasma pneumonia is not visible in gram stain because it doesn`t have cell wall.
Mycobacterium tuberculosis stain blue because it has a thick lupid layer.
The gram reaction depends on the thickness of the peptidoglycan layer.

QUESTION EIGHT

Which of the following diseases is caused by aspergillus spp?

Allergy
Pharyngitis
Keratitis
Bronchopneumonia
Paranasal sinusitis

QUESTION NINE

Bacteria that commonly cause osteomyelitis include:

Haemophillus influenza
Anaerobic bacteria
Pseudomonas aeruginosa
Staphylococcus aureus
Candida albicans

QUESTION TEN

AIDS defining illness include

Pulmonary TB
Diarrhoea
Dementias
Pneumocystis carinii pneumonia
Oral candidiasis

QUESTION ELEVEN

In HIV positive persons, pneumonia is commonly caused by

Pneumocystis carinii
Toxoplasma gondii
Cytomegabvirus
Mycobacterium tuberculosis
Spretococcus pneumonia.

QUESTION TWELVE

A patient with UTI, pus cells positive, culture negative could have the following possibility.

A fastidious organism causing UTI
Partially treated with antibiotics
Could be having renal TB
Sample of the patient with profuse vaginal discharge
The process used for processing culture was incorrect

QUESTION THIRTEEN

Entry of micro-organisms into the urinary tract

Is most often via the blood stream
Is most often around the urethral meatus
Its is assisted by sexual intercourse
Is more likely when a urinary catheter is present.
Is more common in males.

QUESTION FOURTEEN

The number of bacteria per mililitre of urine in mid stream urine specimen (MSU) is

Raised prior to significant pyuria in UTI
Used as an indicator of UTI
Usually > 103/ml in urine
The only factor used to assess the significance of culture results
Often < 105/ml ub staphylococcal UTI.

QUESTION FIFTEEN

Which of the following is TRUE regarding hepatitis B virus infection?

It rarely leads to hepatocellular carcinoma.
Persistence of HBsAg for more than 6 months indicates chronic stage.
HBV infection associated with Delta virus leads to cirrhosis.
Presence of HBc IgM antibody indicates acute infection.
The vaccine contains HBe antigen.

QUESTION SIXTEEN

Which of the following organisms cause folliculitis

Staphylococcus aureus
Aeromonas spp.
Malassezia furfur
Actinomycetes spp.
Mycobacterium ulcerans.

QUESTION SEVENTEEN

Which of the following factors limit the bacterial growth on the skin?

Moisture
Shedding of squames
Salt content
Surface occlusion
Indigenous flora.

QUESTION EIGHTEEN

Factors determining the effectiveness of chemical disinfection include.

Prior cleaning of the article.
Concentration of the chemical disinfectant used
Duration of exposure
Contained used for the disinfectant procedure
Mineral content of the water used for dilution of the disinfectant.

QUESTION NINETEEN

Candidiasis can be treated with

Griseofulvin
Mebendazole
Fluconazole
Amphotericin B
Miconazole.

QUESTION TWENTY

____________ inhibits bacterial cell wall synthesis by blocking a lipid carrier.

Cephalosporin
Phosphonomycin
Bacitracin
Cycloserine
Penicillin.

SECTION B

QUESTION TWENTY ONE

List the similarities between passive diffusion and facilitated diffusion.(5marks)

QUESTION TWENTY TWO
Draw a well labeled diagram of a virus. (5marks)

QUESTION TWENTY THREE
Outline FIVE differences between prokaryotic and eularyotic cells. (5marks)

QUESTION TWENTY FOUR
Name FIVE types of RNA viruses. (5marks)

QUESTION TWENTY FIVE
Describe the bacterial endospores. (5marks)

QUESTION TWENTY SIX

Outline the chief mechanisms by which bacteria acquire resistance to
antibiotics. (5marks)

SECTION C

QUESTION TWENTY SEVEN
a) What precautions should be taken to prevent the spread of methicillin – resistant staphylococcus aureus (MRSA) infection from patient to patient in an ophthalmic ward. (10marks)

b) Discuss classification of viruses. (10marks)

QUESTION TWENTY EIGHT
a) Describe FOUR categories of bacteria according to oxygen requirements.
(8marks)

b) Define the term pathogen and name FIVE pathogenic species of
Escheridhia coli. (6marks)

c) Describe bacterial endospores and list FOUR pathogenic spore forming
bacteria. (6marks)

QUESTION TWENTY NINE
a) Discuss the pathogenesis of tetanus. (10marks)

b) Outline the pathogenesis of bacillary dysentery. (10marks)

Mbio 205:Advanced Microbiology Question Paper

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