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Mbio 205:Advanced Microbiology Question Paper

Mbio 205:Advanced Microbiology

Course:Medical Laboratory

Institution: Kenya Methodist University question papers

Exam Year:2012

KENYA METHODIST UNIVERSITY

END OF 3''RD ''TRIMESTER 2012 (EVENING) EXAMINATIONS
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY SCIENCES
UNIT CODE : MBIO 205
UNIT TITLE : ADVANCED MICROBIOLOGY
TIME : 2 HOURS

INSTRUCTIONS:

Answer ALL Questions in Section A and B and ANY TWO in Section C

SECTION A

QUESTION ONE

Plasmids are important to the genetics of many bacteria. This is because

They are inherited from one generation to the next
They may carry genes that give their host a selective advantage
They can render bacteria drug resistant
All of the above

QUESTION TWO

The 70s prokaryotic ribosome consist of

Two 40s subunits
A 50s and a 30s subunit
A 40s and a 30s subunit
A 50s and a 20s subunit

QUESTION THREE

Gram positive cells

Have a second outer membrane that helps retain the crystal violet stain
Have a multiple layer of petidoglycan that help retain the crystal violet stain
Have a thick capsule that traps the crystal violet stain
Have a periplasmic space that traps the crystal violet.

QUESTION FOUR

The outer membrane of gram negative cells is more permeable than the plasma membrane because

LPS is larger than most membrane phospholipids
Lipoproteins stretch the outer membrane
Porin proteins establish holes in the outer membrane
The core polysaccharide spans the lipid bilayer

QUESTION FIVE

Which of the following is not true about capsules and slime layer?

They consist of secreted material lying outside of the bacterial cell wall.
They can prevent desiccation of bacterial cells
They are required for bacteria to grow normally in culture
They help bacterial resist phagocytosis by macrophages

QUESTION SIX

Fimbriae

Attach bacteria to various surfaces
Cause bacteria more through fluids
Sense changes in nutrient concentration
Are the pathways for the secretion of exoenzymes.

QUESTION SEVEN

What is the purpose of bacteria endospore?

Allow the bacterium to make hundreds of "seeds" to spread on the
Help the bacterium to differentiate into faster growing stages of bacteria
Allow the bacterium to survive the absence of oxygen
Allow the bacterium to survive the extended periods of heat or dryness.

QUESTION EIGHT

Which of the following are obligate intracellular parasites

Viruses
Chlamydia
Rickettsia
All of the above

QUESTION NINE

Staphylococcus grows on/in the _______ of warm blooded animals

Skin and mucus membranes
Teeth
Large intestines
Genital tract

QUESTION TEN

Which of the following is associated with dental caries

Streptococcus preumoniae
Streptococcus mutans
Lactococcus lactis
Staphylococcus aureus

QUESTION ELEVEN

Which of the following is responsible for food spoilage even in canned foods?

Clostridium perfringens
Clostridium botulinum
Clostridium tetani
Clostridium welchi

QUESTION TWELVE

Which of the following genera produce useful antibiotics

Clostridium
Leuconostic
Bacillus
All of these

QUESTION THIRTEEN

Fungi

Are photosynthetic
Are prokaryotic
Secrete extracellular enzymes to break down nutrients
Reproduce by binary fission.

QUESTION FOURTEEN

Which of the following would not be associated with fungi?

Mitochondria
Cell walls
Chloroplasts
Hyphae

QUESTION FIFTEEN

Gram positive cells

Have thick, homogenous cells walls
Have large amounts of teichoic acids
Do not have an outer membrance
All of the above are true.

QUESTION SIXTEEN

The most important role of the prokaryotic cell wall is to

Maintain the shape of the cell
Protect the cell from osmotic pressures
Prevent ions from diffusing away from the cell
Block the effects of antibiotics like penincillin.

QUESTION SEVENTEEN

A bacillus bacterium with a single flagellum at each end is described as

Montrichous
Amphitrichous
Lophotrichous
Peritrichous

QUESTION EIGHTEEN

Which of the following is not a semisynthetic chemotherapeutic agent?

Ampicillin
Carbenicillin
Methicillin
Penincillin

QUESTION NINETEEN

Which of the following protein synthesis mechanism may be affected by particular drugs?

Peptide bond formation
MRNA reading
MRNA translocation
Aminoacyl - tRNA
All of the above

QUESTION TWENTY

Most antibiotics are isolated from

Viruses
Fungi
Acquatic micro-organisms
Soil micro-organisms.

SECTION B (20marks)

QUESTION TWENTY ONE

Compare and contrast the gram positive and gram negative cell walls

QUESTION TWENTY TWO

Differentiate bacteria transduction with bacteria transformation

QUESTION TWENTY THREE

Discuss prions.

QUESTION TWENTY FOUR

Giving relevant examples differentiate bacteria exotoxins with bacterial

endotoxins.

SECTION C(30marks)

QUESTION TWENTY FIVE]
Discuss water, temperature and the major, elements as required for microbial growth. (15marks)

QUESTION TWENTY SIX

Discuss viruses in relation to the nucleic acid (DNA/RNA) classification.
(15marks)

QUESTION TWENTY SEVEN
Describe the stages of bacterial pathogenesis. (15marks)

Mbio 205:Advanced Microbiology Question Paper

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