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Dmls 032:Clinical Chemistry Iii Question Paper

Dmls 032:Clinical Chemistry Iii

Course:Medical Laboratory

Institution: Kenya Methodist University question papers

Exam Year:2013

CLINICAL CHEMISTRY III (DLMS 032) 3RD TRIMESTER 2013

KENYA METHODIST UNIVERSITY

END OF 3RDTRIMESTER 2013 (DAY) EXAMINATION
SCHOOL : MEDICINE & HEALTH SCIENCES
DEPARTMENT : MEDICAL LABORATORY
UNIT CODE : DMLS 032
UNIT TITLE : CLINICAL CHEMISTRY III
TIME : 2 HOURS

INSTRUCTIONS : Answer ALL Questions in Section A and B, choose the most appropriate answer in Section A

SECTION A

Question One

In the glucose oxidase method of estimation of blood glucose, glucose is oxidised to:

* Gluconic acid
* Glucaric acid
* glucuronic acid
* All the above.

Question Two

Glucokinase is mainly found in

* Muscle
* Brain
* Liver
* Lungs

Question Three

The main sample taken from a patient during a glucose tolerance test are:

* Blood and saliva
* Blood and urine
* Urine and cerebrospinal fluid
* Blood and cerebrospinal fluid.

Question Four

The main principle in the estimation of blood glucose by the modified Asatoor and king method is:

* Reduction of cupric ions by glucose
* Oxidation of cupric ions by glucose
* Reduction of glucose by glucose oxidase
* Oxidation of glucose by glucose oxidase.

Question Five

Cholesterol and glyceride testing is done for the following except:

* Screen for lipid disorder
* Check for response to medication to treat lipid disorders.
* In such symptom presentation as Xanthomatosis
* Check for the progress of retinoblastoma.

Question Six

Which of the following pair of markers can be used as prostate cancer markers?

* PSA and acid phosphatase
* PSA and alkaline phosphatase
* LDH and PSA
* LDH and acid phosphatase

Question Seven

The approximate volume of CSF in an adult is:

* 300 ml
* 400 ml
* 150 ml
* 250 ml

Question Eight

CSF is formed by the choroid plexus situated within

* Cerebral cortex
* Ventricles
* Celebrrum
* Pons

Question Nine

The normal glucose levels in the CSF is

* 50 – 70 mg/dl
* 20 -40 mg/dl
* 80 – 130mg/dl
* 0 - 20 mg/dl

Question Ten

The Meuleman`s reagent used in the estimation of total protein in CSF is composed of

* Sodium sulphate and sulphosalicylic acid
* Calcium sulphate and sodium sulphate
* Potassium sulphate and sulphosalicylic acid
* Calcium sulphate and sulphosalicylic acid.

Question Eleven

The enzyme that is deficient in phenylketonuria is

* Tyrosinase
* Phenlalanine hydroxylase
* Alanine transferase
* Tyrosine decarboxylase.

Question Twelve

A patient had pigment lacking in his eyes. What condition is this?

* Albinism
* Alkaptonuria
* Phenylketonuria
* Dystrophy.

Question Thirteen

When analyzing a sample, the technician used the wrong wave length. What type of error did he commit.

* Pre analytical error
* Post analytical error
* Analytical error
* None of the above.

Question Fourteen

File:CLINICAL CHEMISTRY III (DLMS 032) 3RD TRIMESTER 2013 01.png

Glutamate
oxaloacetate

This reaction is know as:

* Transamination
* Dehydrogenation
* Deamination
* Carboxylation

Question Fifteen

Conversion of arginine to urea is facilitated by which enzyme?

* Urease
* Argininosuccinate lyase
* Arginase
* Ornithine transcarbamoylase

Question Sixteen

Formation of urea takes place in

* Kidney
* Heart
* Stomach
* Liver

Question Seventeen

An enzyme which converts glucose – 1 – phosphate to glucose – 4 phosphate is referred to as

* Hydrolase
* Isomerase
* Dehydrogenase
* Synthase

Question Eighteen

Which of the following enzyme tests cannot be used to assess liver damage?

* ? glutaryl transferase
* Creatine kinase
* Alkaline phosphatase
* Lactate dehydrogenase.

Question Nineteen

Amino acids that can be synthesized by the body are referred to as:

* Essential amino acids
* Ketogenic amino acids
* Glucogenic amino acids
* Non-essential amino acids.

Question Twenty

Which of the following specimens is not likely to be analysed in a clinical chemistry laboratory?

* Spetum
* Stool
* CSF
* Urine

SECTION B

Question One
Outline the procedure of conducting a glucose tolerance test. (5marks)

Question Two
Outline the markers of bone diseases. (5marks)

Question Three
Briefly describe the principle of the estimation of blood glucose using the glucose oxidase method. (5marks)

Question Four
Outline the markers of prostate cancer. (5marks)

Question Five

* Name FOUR enzymes used in diagnosis.

(2marks)

* In which organs are they applied in diagnosis?

(2marks)

* Define iso enzymes

(1mark)

Question Six
State the sources of pre-analytical errors. (5marks)

Question Seven

A blood sample was hemolysed

* What factors could have caused this hemolysis?

(4marks)

* Name TWO analytes that cannot be assayed from this sample. (1mark)

Question Eight
Write short notes on alkaptonuria. (5marks)

Dmls 032:Clinical Chemistry Iii Question Paper

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