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Sbt 305: General Genetics Question Paper

Sbt 305: General Genetics

Course:Bachelor Of Science Microbiology And Biotechnology

Institution: University Of Nairobi question papers

Exam Year:2014

UNIVERSITY OF NAIROBI
UNIVERSITY EXAMINATIONS 2013/2014
OPEN AND DISTANCE LEARNING PROGRAMME
THIRD YEAR EXAMINATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE
SBT 305: GENERAL GENETICS
DATE: AUGUST 21 2014 TIME: 9.00 AM – 12.00
INSTRUCTIONS: ANSWER ALL QUESTIONS FROM SECTIONA AND TWO SELECTED FROM SECTION B.
SECTION A
SHORT ANSWER QUESTIONS (50 minutes , 3 marks each)
1. Explain how body colour affects survival of Biston betularia.
2. Illustrate bacterial conjugation using suitable diagrams.
3. In a genetics class of 100 students, 20% were found unable to taste PTC. assuming two alleles T and t, calculate genotypic and allelic frequencies.
4. Explain how thymine dimmers are monomerized in the dark repair mechanism.
5. Briefly explain any three ways of amalyzing variability.
6. Give any three evidence validating DNA as the genetic material.
7. Explain how one can determine the level of repetition of DNA fractions in eukaryotes.
8. Briefly describe mRNA splicing.
9. Explain uniparental inheritance of CO2 sensitivity in Drosophila.
10. Loop formation is a configuration adopted by chromosome to conform to the effects of inversion. Using an example, explain how loop formation occurs.
SECTION B ANSWER ANY TWO QUESTIONS (20 MARKS)
11.
a. In Drosophila, non-wild type alleles;
x- Vermillion eyes
y – cross veinless (no cross covers I the wings)
z – cut (sniped wing edge)
suppose a three point test cross was conducted involving the following
+/+, z/z, y/y, X, x/x, +/+, +/+
Resultant 8 progeny and types and frequencies were as follows;
x + + 595
+ y z 607
x y + 50
+ + z 45
x y z 94
+ + + 99
x + z 8
+ y + 10
i. Carry out crossing till test cross. (3 marks)
ii. Determine distance between the genes. (12 marks)
b. Briefly describe how one can determine distance between bacterial genes. (5 marks)
12. Discuss factors that alter genetic equilibrium in a population.
13. Discuss Cytoplasmic genetic systems.
14. Describe mutations that cause change in chromosome number.

Sbt 305: General Genetics Question Paper

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