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Pmt 441: Drug Delivery And Drug Interactions Question Paper

Pmt 441: Drug Delivery And Drug Interactions

Course:Bachelor Of Science In Medical Biotechnology

Institution: Maseno University question papers

Exam Year:2011

MASENO UNIVERSITY

UNIVERSITY EXAMINATIONS 2010/2011

FOURTH YEAR SECOND SEMESTER EXAMINATION

FOR THE DEGREE OF BACHELOR OF SCIENCE IN

BIOMEDICAL SCIENCE TECHNOLOGY WITH IT

(MAIN CAMPUS)

PMT 441: DRUG DELIVERY AND DRUG INTERACTIONS

Date: 13th April, 2011 Time: 9.00 —11.00 a.m.

INSTRUCTIONS:

.This paper consists of two sections, A B.

.Answer ALL questions in SECTION A and TWO questions in SECTION B.

MASENO UNIVERSITY ISO 9001: 2008 CERTIFIED

Section A (30 Marks). Answer All Questions in this section

Q 1. List the factors that predispose to adverse drug reactions. (5 marks)

Q 2. Define the following terms as tools of trans-dermal drug delivery;

a) Iontophoresis. (3 marks)

b) Phonophoresis. (3 marks)

Q 3. Outline the mechanisms by which micro-organisms acquire resistance to antibiotics. (8 marks)

Q 4. Explain the following terminologies as employed in parenteral drug administration;

a) Passive targeting. (4 marks)

b) Active targeting. (4 marks)

Q 5. Liposomes have advantages and limitations as drug delivery roots. Explain. (3 marks)

Section B (40 marks)

Answer any TWO questions in this section

Q 6. Using specific examples, briefly discuss the mechanisms of pharmacokinetic drug interactions at the following levels;

a) Absorption. (4 marks)

b) Distribution. (8 marks)

c) Elimination. (8 marks)

Q 7. a) The oral route, though being the conventional and most convenient route Of drug delivery, is problematic for protein and peptide drugs. Discuss this statement. (6 marks)

b) Briefly outline the pharmaceutical methods that may be used to improve the oral bioavailability of peptides and proteins. (14 marks

Q 8. Write short notes on the following;

a) Iatrogenic reactions. (4 marks)

b) Idiosyncratic t reactions. (4 marks)

c) Tolerance. (4 marks)

d) Tachyphylaxis. (4 marks)

e) Super sensitivity. (4 marks)

Pmt 441: Drug Delivery And Drug Interactions Question Paper

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