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Advanced Cellular And Molecular Biology Question Paper

Advanced Cellular And Molecular Biology

Course:Bachelor Of Science

Institution: Kenyatta University question papers

Exam Year:2009

KENYATTA UNIVERSITY
UNIVERSITY EXAMINATIONS 2009/2010
FIRST SEMESTER EXAMINATION FOR THE DEGREE OF BACHELOR OF
SCIENCE
(BIOCHEMISTRY AND BIOTECHNOLOGY)
SBC 331 : ADVANCED CELLULAR AND MOLECULAR BIOLOGY
==============================================================
DATE: TUESDAY 22ND DECEMBER 2009 TIME: 8.00 A.M. – 10.00 A.M.
INSTRUCTIONS
Section A
Answer ANY TWO Questions. (20 marks each)
1. Describe
a) The role of alternative splicing in sex determination in Drosophila
embryos. (12 marks)
b) Chromatin modification in regulating gene expression. (8 marks)
2. a) Using an example, explain the Knudson Two-hit hypothesis (10 marks)
b) Describe the reciprocal translocation that leads to the development of
i) Burkitt’s lymphoma (5 marks)
ii) Philadelphia chromosome associated with Chronic Myelogenous
Leukemia. (5 marks)
Page 2 of 2
3. a) What are the properties for a bacterial plasmid designed for cloning.
(15 marks)
b) List Five main types of bacteria plasmids and state the main characteristic
coded by the plasmid genes. (5 marks)
SECTION B
Answer ALL Questions
4. Describe the general structure of a eukaryotic gene. (10 marks)
5. a) Describe THREE alterations in the eukaryotic RNA post transcription.
(6 marks)
b) List the various types of RNA polymerase together with their roles.
(4 marks)
6. a) Using examples, explain the following types of mutations. (6 marks)
i) Synonymous mutation
ii) Missense mutations
iii) Nonsense mutations
iv) Frame-shift mutations
b) Differentiate between somatic and germinal mutation. (2 marks

Advanced Cellular And Molecular Biology Question Paper

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