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Virology Question Paper

Virology

Course:Diploma In Medical Laboratory Science

Institution: Kenya Medical Training College question papers

Exam Year:2012

KENYA MEDICAL TRAINING COLLEGE
DEPARTMENT OF MEDICAL LABORATORY SCIENCE
COLLEGE EXAMINATIONS 2012
BASIC DIPLOMA IN MEDICAL LABORATORY SCIENCE
PAPER; 08-A VIROLOGY
DATE;.......... DAY:................. TIME:........

INSTRUCTIONS
1. Write your index number on every answer sheet
2. Do not write your name on any answer sheet
3. Attempt both sections, I and II

SECTION I COMPRISES OF M.C.Q
4. Circle the correct answer(s) in every question
5. Be careful, as 1/2 mark will be deducted for every wrong response

SECTION II COMPRISES OF ESSAY QUESTIONS
6. Attempt all the questions. Make sure you understand the question before answering

SECTION I (MCQ 40 MARKS)
1. Viruses are:
a) Larger than bacteria
b) Same size as bacteria
c) Smaller than bacteria
d) Obligate extracellular parasites
e) Obligate intracellular parasites

2. Antibiotics are added to transport medium to:
a) Promote bacterial growth
b) Inhibit fungal growth
c) Enrich the medium
d) Prevent bacterial infection
e) Promote fungal infection

3. Which of the following is/are pyrimidines?
a) Guanine
b) Uracil
c) Thymine
d) Cytosine
e) Adenine

4. The following statement(s) is/are true about viruses except:
a) Are isolated from ordinary culture media
b) Do not possess cellular organelle
c) Invisible with light microscope
d) Unicellular organisms comprising of either DNA or RNA
e) Sensitive to antibiotics

5. Nucleic acids are made of small subunits called:
a) Caps meres
b) Nucleocaspid
c) Ribosomes
d) Caspid
e) Nucleotides

6. The information required for the virus to replicate is contained in:
a) Cytoplasm
b) Viral genome
c) Nucleic acid
d) Caspid
e) Viral enzymes

7. Record keeping is necessary in any laboratory for:
a) First aid
b) Reassurance
c) Normalcy
d) Leisure
e) Future reference

8. Non-enveloped viruses are called:
a) Identical viruses
b) Naked viruses
c) Viral subunits
d) Progeny virions
e) Ventices

9. A genome is;
a) A caspid
b) A viral envelope
c) A viral genetic material
d) A capsomere
e) A viral enzyme

10. Which of the following is a good laboratory practice?
a) Working carefully when not gloved
b) Smoking after washing hands
c) No drinks or food in the laboratory
d) Mouth pipetting
e) Applying make-up

11. The Human Immunodeficiency Virus (HIV) possesses the following proteins:
a) GP 120
b) NA
c) GP 41
d) Genome
e) GP 501

12. Constant presence of a disease in a community is referreda) Guanine to as:
a) Endemic
b) Epidemic
c) Pandemic
d) Incidence
e) Prevalence

13. Ideal and specific test to identify nucleic acid material in patients sample is:
a) RIA
b) FFT
c) PCR
d) ELIZA
e) RPHA

14. For serological diagnosis of viral diseases blood samples should be collected at:
a) Two weeks after onset of the disease
b) After recovery from the disease
c) The acute phase
d) Convalescent period
e) Soon after onset

15. Most DNA viruses replicate and assemble in the:
a) Cytoplasm
b) Nucleus
c) Chromosome
d) Cell membrane
e) Ribosome

16. Polymerase chain reaction technique is useful in:
a) Monitoring viral road during ARV therapy
b) Screening blood donors
c) Surveillance of HIV infections
d) Determining the HIV status of infants
e) Producing a same day or hour result

17. Synthesis of mRNA from ADNA strands is called:
a) Transcription
b) Translation
c) Assembly
d) Uncoating
e) Replication

18. The following enzymes are produced during early translation:
a) DNA ligase enzyme
b) Primase
c) DNA polymerase
d) Integrase
e) Reverse transcriptase

19. DNA is organized into functional units referred to as:
a) Icosahedral
b) Genes
c) Autosomes
d) Phosphates
e) Ribosomes

20. Tissue tropism refers to:
a) Cells that a virus readily infects
b) Cells that lack the receptors that virus use to attach
c) Cells that certain bacteriophage only infect
d) Cells that are non-permissive

21. Nucleic structure consists of which of the following components:
a) Phosphate
b) Hydroxyl group
c) Bases
d) Sugar
e) Adenine

22. DNA differs from RNA in that:
a) DNA is double stranded
b) It is made of ribose sugar
c) DNA has uracil instead of thymine
d) DNA is made of deoxyribose sugar

23. Nucleotides are joined together by:
a) Hydrogen bond
b) Phosphodiester bond
c) Covalent bond
d) Peptide bond

24. Which of the following can be associated with HIV infection:
a) Kaposi sarcoma
b) Arthritis
c) Diabetes
d) Tuberculosis
e) Herpes zoster

25. A curious disease spread by ritual cannibalism in papua new guinea is:
a) Borine spongitorm encephalopathy
b) Transmissible mink
c) Scraple of sheep
d) CJD
e) Kuru

26. The intergrated retroviral DNA genome is called:
a) A germ cell
b) A virus
c) A virus host complex
d) A provirus circular DNA

27. The region of a bacteriophage that contains proteins is called:
a) The head
b) The tail fiber
c) The envelope
d) The fiber only
e) The peplomer

28. The region of a bacteriophage that contains the nucleic acid is:
a) The sheath
b) The mitochondria
c) The tail fiber
d) The head
e) The peplomer

ESSAY QUESTIONS
1. Outline the life-cycle of HIV-1 (20 marks)

2a) Outline five differences between RNA and DNA (10 marks)
b) Describe the steps in DNA replication (10 marks)

3a) Complete the following virological abbreviations;
i. RNA
ii. DNA
iii. HIV
iv. CD4
v. ART (10 marks)

b) Write short notes on:
i. Bacteriophage (5 marks)
ii. Mutation (5 marks)

Virology Question Paper

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