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Bcm 2111 : Biochemistry Question Paper
Bcm 2111 : Biochemistry
Course:Bachelor Of Science In Clinical Medicine
Institution: Jomo Kenyatta University Of Agriculture And Technology question papers
Exam Year:2013
JOMO KENYATTA UNIVERSITY
OF
AGRICULTURE AND TECHNOLOGY
University Examinations 2013/2014
FIRST YEAR FIRST SEMESTER EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN CLINICAL MEDICINE
BCM 2111 : BIOCHEMISTRY
DATE: AUGUST 2013 TIME: 2 HOURS
INSTRUCTIONS: ANSWER ALL QUESTIONS IN SECTION A,
SECTION B AND SECTION C.
______________________________________________________________________
SECTION A: ANSWER ALL QUESTIONS (COMPULSORY) 50 MARKS
Q1. With the aid of structures, describe the following sugars:
(a) -D-glucopyranose. [1 mark]
(b) Lactose. [1½ mark]
(c) Glycogen. [2½ marks]
Q2. Write briefly on classic galactosemia. [5 marks]
Q3. Enumerate ten functions of the liver. [5 marks]
Q4. Explain the following reactions of amino acids:
(a) Oxidative deamination. [2½ marks]
(b) Transamination. [2½ marks]
Q5. Outline the classification of amino acids based on their structures. [5 marks]
Q6. Enumerate five physical properties of amino acids. [5 marks]
Q7. With examples, explain the biological functions of phospholipids.
[5 marks]
Q8. Draw the structure of a pyrimidine and purine base and explain the Watson-Crick base pairing which occurs between nucleotides.
[5 marks]
Q9. Explain in detail the principle and application for polymerase chain reaction. [5 marks]
Q10. Draw the structure and explain the health benefits of cholesterol.
[5 marks]
SECTION B: (ANSWER ALL QUESTIONS] 40 MARKS
Q1. Using an illustration, describe the interrelationship between urea and Tricarboxylic acid cycle. [20 marks]
Q2. (a) Describe the reaction steps of glycogen synthesis from
glucose in humans. [10 marks]
(b) Explain in detail the biochemical process of fatty acid oxidation. [10 marks]
SECTION C: MULTIPLE CHOICE QUESTIONS
(ANSWER ALL QUESTIONS] 10 MARKS
Q1. The simple sugars D-glucose and D-mannose are best described as:
(a) Ketosugars.
(b) Pentose sugars.
(c) Epimers.
(d) Sugar acids.
(e) Enantiomers.
Q2. Essential fructosuria in humans is caused by lack of the following enzyme in the liver:
(a) Hexokinase.
(b) Galactokinase.
(c) Lactose.
(d) Fructokinase.
(e) Phosphofructokinase.
Q3. Lactose synthesis in epithelial cells of mammary glands in lactating mothers occurs in the:
(a) Nucleus.
(b) Cell membrane.
(c) Lumen of golgi apparatus.
(d) Mithochondria.
(e) Lysosomes.
Q4. Beriberi is a medical condition caused by deficiency of Vitamin B1 (Thiamine) a source of Thiamine pyrophosphate. This co-factor is required by the following enzymes of energy metabolism:
(a) Aldolase and hexokinase.
(b) Fumarase and succinate dehydrogenase.
(c) Triose phosphate isomerase and aldose reductase.
(d) Enolase and citrate synthesis.
(e) Pyruvate dehydrogenase and ketoglutarate dehydrogenase.
Q5. Amino acids are ampholytes because they can function as:
(a) Uncharged compounds.
(b) Light absorbing compounds.
(c) Neutral ions or molecules.
(d) Polar or non-polar molecules.
(e) Acids or bases.
Q6. Which of the following amino acids is exclusively ketogenic?
(a) Threonine.
(b) Phenylalanine.
(c) Leucine.
(d) Tyrosine.
(e) Isoleucine.
Q7. The following amino acid is essential in the formation of disulphide bonds:
(a) Cysteine.
(b) Tyrosine.
(c) Proline.
(d) Methionine.
(e) Tryptophan.
Q8. The key enzyme in the regulation of fatty acid biosynthesis is:
(a) Acetyl CoA carboxylase.
(b) AMP activated protein kinase.
(c) Protein phosphatase.
(d) Hexo kinase.
(e) None of these.
Q9. In the intestine, dietary fats are hydrolyzed by:
(a) Triacylglycerol lipase.
(b) Adenylate cyclase.
(c) Pancreatic lipase.
(d) Protein kinase.
(e) Pancreatic proteases.
Q10. Which pyrimidine base contains an amino group at carbon 4?
(a) Cytosine.
(b) Thymine.
(c) Uracil.
(d) Adenine.
(e) Guanine.
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