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Mls 2209: Principles Of Immunology Question Paper
Mls 2209: Principles Of Immunology
Course:Bachelor Of Science In Medical Laboratory Science
Institution: Jomo Kenyatta University Of Agriculture And Technology question papers
Exam Year:2012
JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
UNIVERSITY EXAMINATIONS 2012/2012
EXAMINATION FOR THE DEGREE OF BACHELOR OF SCIENCE IN MEDICAL LABORATORY SCIENCE
MLS 2209: PRINCIPLES OF IMMUNOLOGY
DATE: AUGUST 2012 TIME: 2 HOUR
SECTION A – ANSWER ALL QUESTIONS
1. An insect bite may result in inflammation on the spot. It is trigeled by alarm chemicals such as
a) Histamine and dopamine
b) Histamine and kinins
c) Interferon and opsomis
d) Interferons and histones
2. Which is the most abundant immunoglobulin
a) I A
b) Ig D
c) Ig G
d) Ig M
3. Acquired imuniity is found in
a) Invertebrates
b) Vertebrates
c) Some invertebrates
d) Both vertebrates and invertebrates
4. A person is injected with gammaglobihin against Hepatitis B. it is
a) Artificially acquired passive immunity
b) Artificially acquired active immunity
c) Naturally acquired active immunity
d) Naturally acquired passive immunity
5. Antigen binding site in an antibody is found between
a) Two light chains
b) Two heavy chains
c) One heavy and light chain
d) Both B and C
6. Binding of antigen to antibody is through
a) Disulphide brides
b) Amide formation
c) Counlent bonds
d) Electrostatic interactions
7. The characteristics of acquired immunity are
a) Differentiation of self and non-self
b) Specificity
c) Memory
d) All the above
8. Inflammation reaction is due to
a) Plasma cells
b) Most cells
c) Macrophages
d) Actipose cells
9. Macrophages are derived from
a) Neutrophils
b) Lymphocytes
c) Monocytes
d) Basophils
10. Which one of the following helps in the differentiation of cells of the immune system
a) Cortisol
b) Thymosin
c) Steroid
d) Thyroxine
11. Progenitors formed in bone marrow but differentiating elsewhere are
a) Pre – NK cells
b) Pre – enythrocytes
c) Pre – T cells
d) Myeloblasts
12. Which statement about hypersensitivity is correct.
a) Type III and II hypersensitivity are similar but differ in that type III reactions involve self antigens and Type I reactions do not
b) Machators of Type IV hypersentivity include IF gamma
c) Histamine and leukotnenes released by mast cells ate mechators of inflammation and not hypersensitivity
d) Type I hypersensivity is mediated by IgE, IgM and IgE
13. The order of activation of the proteins of complement in the classical pathway is
a) C1 C2 C3 C4 C5
b) C1 C4 C2 C3 C5
c) C2 C1 C3 C4 C5
d) C4 C1 C2 C3 C5
14. The following are hypersensitivity reactions
a) Atopy
b) Tuberculosis
c) Leishmaniasis
d) Schistosomiasis
15. Graft rejection is mediated by
a) T – Lymphocytes
b) B – Lymphocytes
c) Complerent
d) All the above
16. The antigen binding end of the immunoglobulin molecule is at the
a) VH and CH domain
b) VH and VL domain
c) CH and CL domain
d) Carboxyl end
17. Regulation of the alternative pathway is by
a) C Inhibitor
b) Decay Acceleration Factor
c) Factor B
d) Factor D
18. Which of the following is an autoimmune disowa
a) Schistosomiasis
b) Leprosy
c) Tuberculosis
d) Hastimotos disease
19. Immunogenicity depends on
a) Molecular weight of antigen
b) Nature of determinants
c) Degree of foreignness
d) All the above
20. T – helper lymphocytes recognize antigens in association with
a) HLA
b) MHZ
c) MHL class I
d) MHL class II
SECTION B
21. Explain the saherit features that distinguish B and T – Lymophocytes
22. Briefly describe the process of phagocytosis
23. Describe briefly the function of complement products
24. Describe briefly Type III hypersensitivity
25. Describe the primary and secondary immune response
SECTION C Answer any one question (20 marks)
26. Using well labeled diagrams, describe the cells of the immune system.
27. Write an essay on Type III and IV hypersensitivity reactions
28. Write an essay on characteristics and functions of immunoglobulin classes
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