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Mls 2300: Clinical Chemistry I Question Paper
Mls 2300: Clinical Chemistry I
Course:Bachelor Of Science In Medical Laboratory Science
Institution: Jomo Kenyatta University Of Agriculture And Technology question papers
Exam Year:2012
JOMO KENYATTA UNIVERSITY
OF
AGRICULTURE AND TECHNOLOGY
University Examinations 2012/2013
YEAR III SEMESTER I EXAMINATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE
MLS 2300: CLINICAL CHEMISTRY I
DATE: AUGUST 2012 TIME: 2 HOURS
INSTRUCTIONS: ANSWER ALL QUESTIONS
1. Which of the following cells are directly involved in the formation of plaque:
a. Hepatocytes
b. Epithelial
c. Red blood cells
d. Scavanger
2. Which of the following statement is NOT true about HDL-cholesterol:-
a. Contains more protein than cholesterol
b. Contains less proteins and more cholesterol
c. Also referred to as good cholesterol
d. It is not responsible for the formation of plaque
3. Lipid profile constitutes the following parameters:
a. TC, TG, HDL-C, LDL-C and amylase
b. TC, TG, LDL-C and Lipase
c. HDL-C, LDL-C, TG, TC and HDL – C/TG ratio
d. TG, TC, LDL-C, HDL-C and TC/HDL-C ratio
4. The enzyme responsible for the catalysis of the following equation is:
2H_2 O_2+4-AAP+Phenol?Quinoneimine+H_2 O
a. Cholesterol esterase
b. Cholesterol oxidase
c. Urease
d. Peroxidase
5. In the metabolism of glucose, insulin and glucagon have a common characteristic:
a. Act on the same body cells
b. Promotes gluconeogenesis
c. Promotes glycogenolysis
d. Have the same effect in control of blood glucose
6. The chronic hyperglycemia of diabetics is associated with long-term damage, dysfunction and failure of the following organs:-
a. Thyroid gland
b. Skin
c. Kidneys
d. Intestines
7. Which of the following statement best describes gestational diabetes mellitus:
a. Common in all pregnant women.
b. Affects some pregnant women.
c. It is a permanent pathological disorder
d. It is similar to type one diabetes meditus
8. A blood glucose concentration of1 -2 mmol/L can be describe as:
a. Hyperglucome
b. Hypokalaemic
c. Hypoglycaemic
d. Normal
9. Which of the following as not a laboratory technique for the estimation of glycosylated haemoglobin.
a. Cation-exchange chromatography
b. Gel – electrophorescis
c. Affinity chromatography
d. ion selective electrode.
10. The liver functional complexity is attested by the fact that:
a. Whole liver transplantation has been achieved.
b. Liver pathological disorders are very low.
c. Complicated liver pathological disorders affect only old people
d. Reconstitution of an artificial or bio artificial liver is yet to be achieved
11. The following Biochemical parameter has a higher investigative power for alcoholic liver disease:
a. total protein
b. Troponin
c. rGT
d. B.U.N
12. In the laboratory determination of total bilivubin levels of a blood specimen, caffeine is used to:
a. Enhance the purple colour
b. Accelerate the reaction
c. Co-facor of the reaction
d. To stope the chemical reaction
13. During the interpretation of a female fertility hormonal profile, the laboratory report depends on:-
a. Instrument of analysis
b. Menstrual phase of the female client
c. The person doing the interpretation
d. The level of the laboratory
14. Which of the following is NOT an analytical method for the estimation of sodium in serum.
a. Flame photometry
b. Colorimetric
c. Electrophonesis
d. Ion selective electrodes
15. Testosterone levels in a female are raised during which phase of the menstrual cycle
a. follicular
b. Lateal
c. Ovulation
d. Bleeding
16. The functional relationship between the pituitary and the target glands is based on:-
a. Hypothalamic dysfunction
b. Secretion of releasing hormones
c. Feedback mechanisms regulations
d. Maintenance of target glands secretion
17. HBAIc is a test carried out on patient being managed for the following pathological disorder:
a. Anaemia
b. Bleeding
c. Diabetes mellitus
d. Sickle cell trait
18. Serum specimen having a lot of Bilirubin can be describe as:
a. Haemolyzed
b. Iceteric
c. Lipaemic
d. Cloudy
19. Which of the following constitute a complete thyroid function test profile:
a. T3, T4 anti TSH
b. LH, FSH, PRL, TSH
c. T3, T4, TSH, FT3 FT4
d. GLU, AST, FT3, FT4, TSH
20. The following group of enzymes is analyzed in the investigation of mycarodial infarcation:
a. CPK, AMY, LIP
b. MP, AST, CPK, MPH
c. CPK, AST, LDH
d. AST, BUN, CPK
SECTION B (ATTEMPT ALL QUESTIONS) (30 MARKS)
21. Describe the goals of clinical chemistry. (6 marks)
22. Briefly describe the three distinct processes that take place in each nephron resulting with production of urine. (6 marks)
23. Briefly describe the current application of ion selective electrode in the estimation of sodium and potassium. (6 marks)
24. Given the weight of intracellular fluid of an individual as 60Kg, calculate:
a. Total body weight. (3 marks)
b. Extracellular fluid weight. (3 marks)
25. Briefly describe the following fertility hormones condition.
a. Impotence (3 marks)
b. Menopause (3 marks)
SECTION C (ANSWER ONLY ONE QUESTION) (20 MARKS)
26. Discuss the two approaches recommended for the screening of gestational diabetes mellitus.
(20 marks)
27. The following is a clinical chemistry report of a 42 years old female patient attending out
patient clinic in Thika level 5 district hospital.
(BUN = 5 mmol/L, serum creatinine = 84µmol/L, Body
Weight = 68 kg, 24 hours urine volume = 2.36 litres
Urine creatine = 4200 mmol/L, K+ = 4.6 mmol/L Na+ = 138 mmol/c, Height = 1.8 metres, TC = 5.6 mmol/c, TG = 1.2 mmol/c, HDL – C = 1.8mmol/c
a. Determine the measured creatinine clearance. (5 marks)
b. Determine the estimated creatinine clearance. (5 marks)
c. Calculate the LDL – C of the client. (5 marks)
d. Suggest what is missing in the report and give a recommendation. (5 marks)
28. Discuss body fluids imbalances. (20 marks)
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